Month: September 2026

PETAH TIKVA, Israel, Sept. 16, 2026 (GLOBE NEWSWIRE) — TurboGen Ltd. (NASDAQ:TRBG) (TASE:TURB) (“TurboGen” or the “Company”), developer of combined heat and power systems based on multifuel microturbines, today announced the signing of a non-binding  memorandum of understanding (“MOU”) with a U.S. entity that owns and operates residential care and rehabilitation centers in the United States to purchase  approximately 40 units of the Company’s 80Kw combined heat and power (“CHP”) systems to be placed in their facilities, based on the Company’s estimate of the energy demand in those facilities. The MOU contemplates an initial purchase of 40 units, subject to entry into a definitive agreement setting forth the terms of the purchase.

“Our microturbine-based CHP systems provide versatile and efficient power and heat, with our 80Kw systems being specifically designed for larger residential and commercial operations,” stated Yaron Gilboa, TurboGen’s Chief Executive Officer. “This MOU represents recognition within a substantial U.S.-based operation for the specific benefits of our technology, and we look forward to continuing the negotiation process and acquiring this customer.  We further believe this MOU may lead to several potential contracts that represent both the attraction of our uniquely designed technology, and demonstration of shareholder value even in the early days of our Nasdaq listing.”

The Company anticipates providing further updates related to the MOU as they develop, as well as other ongoing business developments.

About TurboGen

Founded in response to technologically address the threat of climate change and the lack of grid capacity, TurboGen Ltd. (NASDAQ:TRBG) (TASE:TURB) develops combined heat and power systems based on multifuel microturbines. These microturbines are used for local electricity, energy, and heat production. To learn more, please visit: https://turbogenchp.com.

Forward Looking Statements

This press release contains forward-looking statements within the meaning of the “safe harbor” provisions of the Private Securities Litigation Reform Act of 1995 and other Federal securities laws. Words such as “expects,” “anticipates,” “intends,” “plans,” “believes,” “seeks,” “estimates” and similar expressions or variations of such words are intended to identify forward-looking statements. For example, TurboGen is using forward looking statement in this press release when it discusses the MOU and entry into a definitive agreement; the potential purchase of approximately 40 units of its CHP systems; the benefits of its technology; and, its future entry into potential contracts. Because such statements deal with future events and are based on TurboGen’s current expectations, they are subject to various risks and uncertainties and actual results, performance or achievements of TurboGen could differ materially from those described in or implied by the statements in this press release. The forward-looking statements contained or implied in this press release are subject to other risks and uncertainties, many of which are beyond the control of the Company, including those set forth in the Risk Factors section of the Company’s Registration Statement on Form F-1 filed with the Securities and Exchange Commission (the “SEC”) on March 12, 2026. Copies are available on the SEC’s website, www.sec.gov. The Company undertakes no obligation to update these statements for revisions or changes after the date of this release, except as required by law.

IR and Communications Contact:

IR@turbogenchp.com

FORM 8.5 (EPT/RI)

Amendment in 1(b)
PUBLIC DEALING DISCLOSURE BY AN EXEMPT PRINCIPAL TRADER WITH RECOGNISED INTERMEDIARY STATUS DEALING IN A CLIENT-SERVING CAPACITY
Rule 8.5 of the Takeover Code (the “Code”)

1.        KEY INFORMATION

(a)        Name of exempt principal trader:	Investec Bank Plc
(b)        Name of offeror/offeree in relation to whose relevant securities this form relates:         Use a separate form for each offeror/offeree	Tribal Group Plc
(c)        Name of the party to the offer with which exempt principal trader is connected:	Investec is Advisor and Joint Broker to Tribal Group Plc
(d)        Date dealing undertaken:	14th September 2026
(e)        In addition to the company in 1(b) above, is the exempt principal trader making disclosures in respect of any other party to this offer?         If it is a cash offer or possible cash offer, state “N/A”	N/A

2.        DEALINGS BY THE EXEMPT PRINCIPAL TRADER

Where there have been dealings in more than one class of relevant securities of the offeror or offeree named in 1(b), copy table 2(a), (b), (c) or (d) (as appropriate) for each additional class of relevant security dealt in.

The currency of all prices and other monetary amounts should be stated.

(a)        Purchases and sales

Class of relevant security	Purchases/ sales	Total number of securities	Highest price per unit paid/received	Lowest price per unit paid/received
Ordinary shares	Purchase	5,000	81.676	81.676

(b)        Cash-settled derivative transactions

Class of relevant security	Product description e.g. CFD	Nature of dealing e.g. opening/closing a long/short position, increasing/reducing a long/short position	Number of reference securities	Price per unit
N/A	N/A	N/A	N/A	N/A

(c)        Stock-settled derivative transactions (including options)

(i)        Writing, selling, purchasing or varying

Class of relevant security	Product description e.g. call option	Writing, purchasing, selling, varying etc.	Number of securities to which option relates	Exercise price per unit	Type e.g. American, European etc.	Expiry date	Option money paid/ received per unit
N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A

(ii)        Exercise

Class of relevant security	Product description e.g. call option	Exercising/ exercised against	Number of securities	Exercise price per unit
N/A	N/A	N/A	N/A	N/A

(d)        Other dealings (including subscribing for new securities)

Class of relevant security	Nature of dealing e.g. subscription, conversion	Details	Price per unit (if applicable)
N/A	N/A	N/A	N/A

3.        OTHER INFORMATION

(a)        Indemnity and other dealing arrangements

Details of any indemnity or option arrangement, or any agreement or understanding, formal or informal, relating to relevant securities which may be an inducement to deal or refrain from dealing entered into by the exempt principal trader making the disclosure and any party to the offer or any person acting in concert with a party to the offer: Irrevocable commitments and letters of intent should not be included. If there are no such agreements, arrangements or understandings, state “none”

None

(b)        Agreements, arrangements or understandings relating to options or derivatives

Details of any agreement, arrangement or understanding, formal or informal, between the exempt principal trader making the disclosure and any other person relating to: (i)        the voting rights of any relevant securities under any option; or (ii)        the voting rights or future acquisition or disposal of any relevant securities to which any derivative is referenced: If there are no such agreements, arrangements or understandings, state “none”

None

Date of disclosure:	16th September 2026
Contact name:	Priyali Bhattacharjee
Telephone number:	+91-9923757332

Public disclosures under Rule 8 of the Code must be made to a Regulatory Information Service.

The Panel’s Market Surveillance Unit is available for consultation in relation to the Code’s dealing disclosure requirements on +44 (0)20 7638 0129.

The Code can be viewed on the Panel’s website at ssssssswwww.thetakeoverpanel.org.uk.

CLEVELAND, Sept. 16, 2026 (GLOBE NEWSWIRE) — Abeona Therapeutics Inc. (Nasdaq: ABEO), a commercial-stage biopharmaceutical company developing genetic medicines for serious diseases with high unmet need, today announced the activation of University of Florida Health (UF Health) in Gainesville, Florida, as the eighth Qualified Treatment Center (QTC) for the administration of ZEVASKYN (prademagene zamikeracel) gene-modified cellular sheets. ZEVASKYN is the first and only autologous gene-modified cellular sheets for the treatment of wounds in patients with recessive dystrophic epidermolysis bullosa (RDEB).

“Activation of UF Health as a QTC represents an important step in expanding access to ZEVASKYN for patients living with RDEB in Florida and the Southeastern United States,” said Dr. Madhav Vasanthavada, Chief Commercial Officer of Abeona. “UF Health is widely recognized for its leadership in dermatology and multidisciplinary patient care, and we are excited to partner with them to bring this innovative gene therapy to eligible children and adult patients in need.”

“The University of Florida Health is now the sole treatment center for ZEVASKYN across the Southeastern United States. This new gene therapy expands the treatment armamentarium for managing epidermolysis bullosa, with the goal of improving skin healing and patient quality of life,” said Michael Lavery, M.D., Clinical Assistant Professor in the Department of Dermatology at the University of Florida and Director of the University of Florida Epidermolysis Bullosa Multidisciplinary Clinic.

“ZEVASKYN brings together the expertise of our Pediatric Surgery and Burn teams and highlights the collaborative care model that defines UF Health. We are proud to partner with Abeona Therapeutics to expand access to specialized treatment for patients with epidermolysis bullosa,” said Dr. Shawn Larson, M.D., Professor and Chief of the Division of Pediatric Surgery at the University of Florida.

UF Health has already initiated patient identification and onboarding activities and is working with Abeona to support treatment access for eligible patients. For more information about receiving ZEVASKYN treatment at UF Health, contact the UF Health Epidermolysis Bullosa (EB) Clinic in Gainesville by calling (352) 594-1500, or by email at eb-clinic@ufl.edu. For more information, visit: https://dermatology.med.ufl.edu/patient-care/epidermolysis-bullosa-ebclinic/.

For more information on how to access ZEVASKYN and learn about patient support services offered through Abeona Assist™, Abeona’s comprehensive patient support program, visit www.abeonaassist.com, call 1-855-ABEONA-1 (1-855-223-6621) or email MyNavigator@AbeonaAssist.com. Abeona Assist offers personalized support, including helping eligible patients understand their insurance benefits and financial assistance options, and providing travel and logistical assistance.

About recessive dystrophic epidermolysis bullosa
Recessive dystrophic epidermolysis bullosa (RDEB), a rare blistering disorder without a cure, is characterized by severe skin wounds that cause pain and can lead to systemic complications impacting the length and quality of life. People with RDEB have a defect in both copies of the COL7A1 gene, leaving them unable to produce functioning type VII collagen, which is necessary to anchor the dermal and epidermal layers of the skin.

About ZEVASKYN^® (prademagene zamikeracel) gene-modified cellular sheets
ZEVASKYN is the first and only autologous cell sheet-based gene therapy for the treatment of wounds in adult and pediatric patients with recessive dystrophic epidermolysis bullosa (RDEB). RDEB is a severe skin disease caused by a defect in both copies of the COL7A1 gene resulting in the inability to produce functional type VII collagen. Without functional type VII collagen and anchoring fibrils, the skin is fragile and blisters easily, leading to wounds that continually open and close, or fail to heal altogether. Patients often have large open wounds that can lead to serious life-threatening complications. ZEVASKYN incorporates the functional type VII collagen-producing COL7A1 gene into a patient’s own skin cells, ex vivo, using a replication-incompetent retroviral vector to produce functional type VII collagen in treated wounds. ZEVASKYN has demonstrated clinically meaningful wound healing and pain reduction with a single surgical application. For more information, visit www.ZEVASKYN.com.

Indication
ZEVASKYN^® (prademagene zamikeracel) is an autologous cell sheet-based gene therapy indicated for the treatment of wounds in adult and pediatric patients with recessive dystrophic epidermolysis bullosa (RDEB).

Important Safety Information
Serious allergic reactions to ZEVASKYN can occur. Patients should get medical help right away if they experience symptoms like itching, swelling, hives, difficulty breathing, runny nose, watery eyes, or nausea. In rare cases, a severe reaction called anaphylaxis may happen. There is a potential risk that treatment with ZEVASKYN may contribute to the development of cancer because of how the therapy works. Patients should be monitored for the rest of their lives to check for any signs of cancer.

ZEVASKYN is made using human and animal materials. Although these materials are tested before use, the risk of passing on infections cannot be eliminated. The most common side effects are pain from the procedure and itching.

This is not a complete list of side effects. Patients should call their care team for medical advice about side effects. Side effects may be reported to Abeona at 1-844-888-2236 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. See full Prescribing Information.

About Abeona Therapeutics
Abeona Therapeutics Inc. is a commercial-stage biopharmaceutical company developing cell and gene therapies for serious diseases. Abeona’s ZEVASKYN^® (prademagene zamikeracel) is the first and only autologous cell-based gene therapy for the treatment of wounds in adult and pediatric patients with recessive dystrophic epidermolysis bullosa (RDEB). The Company’s fully integrated cell and gene therapy cGMP manufacturing facility in Cleveland, Ohio, serves as the manufacturing site for ZEVASKYN commercial production. The Company’s development portfolio features ABO-701 (PSMA-SIR-T™), a potentially first-in-class engineered T-cell therapy targeting PSMA, engineered to overcome the core failures of cell therapies in solid tumors. For more information, visit www.abeonatherapeutics.com.

ZEVASKYN^®, Abeona Assist^®, Abeona Therapeutics^®, and their related logos are trademarks of Abeona Therapeutics Inc.

Forward-Looking Statements
This press release contains certain statements that are forward-looking within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, and that involve risks and uncertainties. We have attempted to identify forward-looking statements by such terminology as “may,” “will,” “believe,” “anticipate,” “expect,” “intend,” “potential,” and similar words and expressions (as well as other words or expressions referencing future events, conditions or circumstances), which constitute and are intended to identify forward-looking statements. Actual results may differ materially from those indicated by such forward-looking statements as a result of various important factors, numerous risks and uncertainties, including but not limited to our ability to maintain existing and obtain additional regulatory approvals of ZEVASKYN® and any future product candidates; our ability to successfully commercialize and market ZEVASKYN® and any future product candidates, if approved, and the timing of any commercialization and marketing efforts; our ability to manufacture sufficient batches of ZEVASKYN® to meet demand; our ability to manufacture ZEVASKYN® batches that meet certain product release specifications that were required by FDA at the time of BLA approval and implemented based on a limited clinical dataset; the FDA’s willingness to revise such release specifications to reflect real-world manufacturing experience; our ability to manufacture from provided biopsy material a ZEVASKYN® batch for which revenue may ultimately be recognized, which depends on such factors as qualified treatment centers obtaining biopsy samples from ZEVASKYN® patients of sufficient quality to act as starting material for manufacturing ZEVASKYN®, patient-to-patient variability in cell growth during the ZEVASKYN® manufacturing process, patient health deterioration in close proximity to ZEVASKYN® treatment such that treatment is no longer possible, and expiration of ZEVASKYN®’s 84-hour shelf-life before surgical application of ZEVASKYN® can be performed; our ability to activate additional qualified treatment centers to administer ZEVASKYN® on patients; the ability of qualified treatment centers to enroll patients for treatment or administer ZEVASKYN® on patients; our ability submit an investigational new drug application for ABO-701 and enroll patients in new clinical trials; our ability to access additional financial resources and/or our financial flexibility to reduce operating expenses if required; our ability to obtain additional equity funding from current or new stockholders; the potential impact of unpredicted changes in the structure and/or administration of the United States government or its agencies; our ability to out-license technology and/or other assets, deferring and/or eliminating planned expenditures, restructuring operations and/or reducing headcount, and sales of assets; the dilutive effect that raising additional funds by selling additional equity securities would have on the relative equity ownership of our existing investors, including under our existing at-the-market sale agreement; the outcome of any interactions with the FDA or other regulatory agencies relating to any of our products or product candidates; our ability to continue to secure and maintain regulatory designations for our product candidates; our ability to develop manufacturing capabilities compliant with current good manufacturing practices for our product candidates; our ability to manufacture cell and gene therapy products and produce an adequate product supply to support clinical trials and potentially future commercialization; the rate and degree of market acceptance of our product candidates for any indication once approved; our ability to meet our obligations contained in license agreements to which we are party; and macroeconomic uncertainty resulting from changes to U.S. trade policy, including current or future tariffs or other trade restrictions.

CONTACT: Contacts:
Investor and Media:
Greg Gin
VP, Investor Relations and Corporate Communications
Abeona Therapeutics
ir@abeonatherapeutics.com

Investor:
Lee M. Stern
Meru Advisors
lstern@meruadvisors.com

380 Meter Hole Completed at Vumba Central; Core Logging Identifies Silica–Carbonate Alteration, Quartz–Carbonate Veining and Sulfides; Full Hole Sampling Planned

Second Drill Hole Underway as Company Advances Approximately 3,000-Meter 2026 Program

TORONTO, Sept. 16, 2026 (GLOBE NEWSWIRE) — One Bullion Ltd. (“One Bullion” or the “Company”) (TSXV: OBUL), a gold exploration company holding complete ownership of three highly prospective exploration projects in Botswana, today announced the completion of diamond drill hole VUDD017 to a final depth of 380 meters at its wholly owned Vumba Gold Project in northeastern Botswana. VUDD017 marks the completion of the first hole of the Company’s approximately 3,000-meter 2026 diamond drilling program, with drilling now underway on the next hole, VUDD018.

The hole tested the Central–Makoba target (VGT-01), a priority exploration area identified through the integration of high-resolution airborne magnetic data, historical drilling, trenching, soil geochemistry and surface sampling. VUDD017 was designed to test the down-dip extension of the interpreted mineralized corridor and generate additional geological and structural data to refine the Company’s exploration model and guide follow-on drilling.

Highlights

• VUDD017 completed to 380 meters at a collar azimuth of 269° true and a dip of −58°, predominantly using HQ-diameter diamond core.
• Logging records an amphibolite-dominated sequence with variable foliation and banding, silica–carbonate alteration, quartz–carbonate veins and veinlets, and locally observed sulfides.
• The Company will sample the full 380-meter hole at nominal one-meter intervals, adjusted to geological contacts, with additional quality-control samples included in submissions to ALS Geochemistry in Johannesburg.
• Geological and structural observations are being incorporated into the three-dimensional model. Drilling of the second hole, VUDD018, has commenced.

“The completion of VUDD017 represents an important step forward in our 2026 exploration program,” said Adam Berk, Chief Executive Officer of One Bullion. “The core logging has identified veining, alteration and sulfides within the amphibolitic host rocks, providing valuable information to refine our geological model and help guide follow-on drilling. We are now progressing full-hole sampling while drilling continues on VUDD018. The resulting assays will be critical to determining the gold content and evaluating the significance of the geological observations identified in the core.”

No assay results for VUDD017 are available. The geological descriptions in this release are based on visual core logging and do not establish gold grade, mineralized widths or economic mineralization.

VUDD017 — Central–Makoba Anchor Hole
VUDD017 was collared within the Central–Makoba target area to cross the interpreted mineralized corridor, which trends approximately north–south. Collar details and the reported completed depth are set out below.

Hole	Easting (mE)	Northing (mN)	Elevation (m)	Azimuth (true)	Dip	Depth (m)
VUDD017	535,976	7,712,693	1,219	269°	−58°	380.0

Coordinates: WGS84 / UTM Zone 35S (EPSG:32735). Azimuth and dip are collar settings; negative dip is below horizontal. Depths are measured downhole.

Preliminary Geological Observations
The hole intersected shallow soil cover and oxidized amphibolitic rock before entering fresh amphibolite at approximately 8.9 meters. The bedrock sequence is predominantly amphibolitic, varying from massive to foliated, schistose and banded, with locally quartz-rich intervals and two narrow intervals logged as metasedimentary rock.

From (m)	To (m)	Lithology / Observation
0.00	1.20	Topsoil / soil cover.
1.20	8.86	Amphibolitic rock with near-surface weathering and oxidation.
8.86	108.72	Predominantly fresh amphibolite, variably massive, foliated, schistose and banded; local veining and silica–carbonate alteration.
108.72	109.27	Narrow metasedimentary interval.
109.27	330.60	Predominantly amphibolite with variable foliation, banding and quartz-rich intervals; repeated silica–carbonate alteration and veining.
330.60	333.10	Metasedimentary rock.
333.10	380.00	Amphibolite, locally foliated or quartz-rich, with variable silica–carbonate alteration and veining.

This is a lithological summary, not a table of gold intersections. Listed depths are downhole and do not represent true widths of mineralization. Alteration and sulfides are variably distributed, not continuous across the intervals shown.

Silicification is recorded as both banded and locally pervasive alteration of the host rock, as well as in quartz-bearing veins. Carbonate alteration and quartz–carbonate or calcite veins and veinlets recur at multiple depths, with local chlorite alteration and brecciation.

Visual logging identifies sulfides provisionally as pyrite and arsenopyrite, with some grains of uncertain identity. Sulfides occur locally within veins and altered wall rock and along foliation or banding. Their presence and distribution are not a measure of gold content. Geological observations are being evaluated against the target interpretation; the position, grade and continuity of any gold-bearing zones remain to be determined.

Sampling, Analysis and QA/QC
Core logging, photography, cutting and sampling are progressing at the Company’s secure core facility. Sampling will cover the full 380-meter hole rather than only visibly altered or sulfide-bearing intervals. Half-core samples will be cut with a diamond saw at nominal 1.0-meter intervals, adjusted to lithological and mineralogical contacts. The remaining half-core will be retained for reference. Certified reference materials, blanks and duplicates will be included in the analytical submissions as part of the quality assurance and quality control (“QA/QC”) program.

Samples will be bagged, sealed and transported under chain-of-custody procedures to ALS Laboratories in South Africa, an ISO/IEC 17025-accredited facility that is independent of the Company. Gold analysis is planned by 30-gram fire assay with atomic absorption finish (Au-AA25), together with multi-element analysis by four-acid digestion and ICP-AES (ME-ICP61a). Samples returning more than 10 g/t gold are planned for gravimetric-finish re-assay (Au-GRA21), with any additional checks determined by the technical team and laboratory.

Structural measurements have been collected where reliable core orientation was available. Geological, sampling and survey records will be reconciled in the Company’s database, and assay results and associated QA/QC will be reviewed before results are released. The Company expects initial assays approximately four to six weeks after receipt of the samples by the laboratory, subject to turnaround times and any additional analytical or verification work.

2026 Drilling Program and Next Steps
The approximately 3,000-meter program comprises 10 planned HQ diamond holes across priority structural corridors at Vumba. The program is being executed by Mindea Exploration and Drilling Services (Pty) Ltd., which mobilized in August 2026, and is managed by Joe Van Wyk, Vice President, Exploration.

The program uses a decision-gated approach: initial holes test the geological framework, with subsequent locations and orientations refined using the geological observations, structural measurements and, when available, verified assays. Following completion of VUDD017, drilling has commenced on VUDD018. The Company will continue integrating new information into its three-dimensional model while progressing sampling and laboratory submissions. Interpretation of the Maitengwe airborne geophysical survey continues in parallel to support future targeting.

Cautionary Note Regarding Visual Observations
Visual identification of alteration, sulfides and quartz–carbonate veins is preliminary and is not a substitute for laboratory analysis. These observations do not establish gold grade, gold-bearing interval lengths, continuity or economic significance. No gold assays from VUDD017 are reported in this release. Analytical results will be disclosed following receipt, compilation and verification.

Qualified Person
The scientific and technical information contained in this news release has been reviewed and approved by Rory Kutluoglu, P.Geo., a “Qualified Person” as defined under National Instrument 43-101 – Standards of Disclosure for Mineral Projects, who is independent of One Bullion.

About One Bullion
One Bullion Ltd. (TSXV: OBUL) is a Toronto-based gold exploration company focused on advancing high-quality gold assets in Botswana, one of Africa’s most stable and mining-friendly jurisdictions. Established in 2018, the Company controls approximately 8,004 km² of prospective land across three greenstone belt-hosted gold projects, including Vumba, Kraaipan, and Maitengwe. One Bullion’s strategy centers on disciplined, data-driven exploration combining modern geological methods with advanced targeting to identify and test high-priority gold targets while maintaining a commitment to environmental stewardship, community engagement, and long-term value creation for stakeholders.

Forward-Looking Information
This news release contains forward-looking information within the meaning of applicable Canadian and U.S. securities laws. Forward-looking information includes statements concerning the scope, sequencing and timing of the Company’s exploration program; completion of core sampling and submission to the laboratory; anticipated analytical methods and assay turnaround; continued drilling; integration of geological, structural and assay data into the three-dimensional model; the location and orientation of subsequent holes; and interpretation and future targeting at Maitengwe. This information is based on management’s current expectations and assumptions, including the availability of funding, personnel, contractors and laboratory capacity; continued access to the projects and maintenance of required permits; the ability to complete sampling and drilling safely; and the suitability of the available geological data for ongoing interpretation. Forward-looking information is subject to risks and uncertainties, including changes in geological interpretations, assay results that do not support visual observations, variable core recovery and sample representativity, drilling or equipment problems, weather and access constraints, permitting delays, laboratory backlogs, additional QA/QC or verification requirements, funding availability and risks associated with operations in Botswana.

Actual results, work programs, costs and timelines may differ materially from those expressed or implied. There is no assurance that further drilling will identify economic mineralization or that the current geological interpretation will be confirmed. Readers should not place undue reliance on forward-looking information. Except as required by applicable law, the Company undertakes no obligation to update or revise it as a result of new information, future events or otherwise.

Cautionary Note Regarding United States Securities Laws
This news release does not constitute an offer to sell or the solicitation of an offer to buy securities, nor shall there be any sale of securities in a jurisdiction in which such offer, solicitation or sale would be unlawful. The Company’s securities have not been registered under the United States Securities Act of 1933, as amended (the “U.S. Securities Act”), or any state securities laws, and may not be offered or sold within the United States or to, or for the account or benefit of, U.S. persons, as defined in Regulation S under the U.S. Securities Act, unless an exemption from registration is available.

Contact Information:
Adam Berk, Chief Executive Officer
OneBullion@KCSA.com

Investor Contact:
KCSA Strategic Communications
Jack Perkins or Valter Pinto
T: 212-896-1254
OneBullion@KCSA.com

NEITHER THE TSX VENTURE EXCHANGE NOR ITS REGULATION SERVICES PROVIDER (AS THAT TERM IS DEFINED IN THE POLICIES OF THE TSX VENTURE EXCHANGE) ACCEPTS RESPONSIBILITY FOR THE ADEQUACY OR ACCURACY OF THIS RELEASE.

HOUSTON, Sept. 16, 2026 (GLOBE NEWSWIRE) — CNSide Diagnostics, LLC, a wholly owned subsidiary of Cerenome, Inc. (Nasdaq: CNSY) (“Cerenome” or the “Company”), today announces the appointment of Samantha Fowlkes as Vice President Head of Commercial Sales. Samantha will lead the commercial expansion of CNSide®, strengthening relationships across the oncology and pathology communities, and accelerate adoption of the CNSide platform by physicians and health systems.

“Samantha brings more than two decades of commercial leadership experience across oncology diagnostics, precision medicine and laboratory services, with a proven ability to build organizations and drive growth,” said Russell Bradley, President and General Manager of CNSide Diagnostics. “Her leadership comes at an important time as we expand CNSide’s reach and build the commercial foundation for Cerenome’s next phase of growth.”

Samantha most recently served as Vice President, U.S. Head of Client Clinical Operations at Caris Life Sciences, where she held senior leadership roles spanning precision medicine, commercial partnerships and clinical operations. She previously held leadership positions in strategic accounts and business development at Genoptix Medical Laboratory and Laboratory Corporation of America.

Samantha holds a Bachelor of Arts and Sciences degree in Cell and Molecular Biology from Texas Woman’s University.   Her career has centered on advancing precision medicine through strategic partnerships and expanding access to innovative diagnostic technologies across the healthcare system.

“CNSide has the potential to change how CNS cancers are detected and monitored, and Cerenome is uniquely positioned to advance that vision,” said Samantha Fowlkes. “I am excited to join the team and help expand CNSide adoption while building a scalable commercial organization focused on improving care for patients with CNS cancers.”

About Cerenome

Cerenome (Nasdaq: CNSY) is a CNS oncology company advancing an integrated platform that combines precision diagnostics, targeted therapeutics, and artificial intelligence to improve outcomes for patients with central nervous system cancers. The Company’s CNSide® Diagnostics platform supports the detection, molecular characterization, and longitudinal monitoring of CNS cancers through cerebrospinal fluid-based testing. Its lead therapeutic platform, REYOBIQ™ (rhenium Re186 obisbemeda), is being evaluated in clinical trials for leptomeningeal metastases, recurrent glioblastoma, and pediatric brain cancers. The data & artificial intelligence platform is designed to integrate diagnostic, molecular, imaging, and clinical data into actionable insights that support precision oncology and therapeutic innovation. By integrating commercial diagnostics, targeted therapeutics, proprietary longitudinal data, and artificial intelligence within a single organization, Cerenome is building a differentiated CNS oncology platform designed to improve patient care while creating long-term shareholder value. Visit https://www.cerenome.com.

About CNSide Diagnostics, LLC

CNSide Diagnostics, LLC is a wholly owned subsidiary of Cerenome, Inc. that develops and commercializes proprietary laboratory-developed tests, such as CNSide^®, designed to identify tumor cells that have metastasized to the central nervous system in patients with carcinomas and melanomas. The CNSide^® CSF Assay Platform enables quantitative analysis of the cerebrospinal fluid that informs and improves the management of patients with leptomeningeal metastases. For more information, visit https://www.cnside-dx.com/.

Forward-Looking Statements

This press release contains statements that may be deemed “forward-looking statements” within the meaning of U.S. securities laws. All statements in this press release other than statements of historical fact are forward-looking statements. These forward-looking statements may be identified by future verbs, as well as terms such as “expect,” “potential,” “anticipating,” “planning” and similar expressions or the negatives thereof. Such statements are based upon certain assumptions and assessments made by management in light of their experience and their perception of historical trends, current conditions, expected future developments and other factors they believe to be appropriate. These statements include, without limitation, the Company’s anticipated growth in CNSide testing volume and reimbursement, the timing and results of REYOBIQ clinical trials, and expectations as to the Company’s future performance and financial position. Actual results may differ materially from those expressed or implied by these forward-looking statements due to a variety of risks and uncertainties, including those described in the Company’s filings with the Securities and Exchange Commission. The Company undertakes no obligation to update any forward-looking statements, whether as a result of new information, future events, or otherwise, except as required by law.

Investor Contact

CORE IR

IR@cerenome.com

Once-daily, oral ART27.13 reduced body weight by approximately 20% in obese mice, matching the weight loss achieved with semaglutide, the active ingredient in Ozempic^® and Wegovy^®

Combining ART27.13 with semaglutide produced approximately 40% weight loss – double that of semaglutide alone

Results indicate that ART27.13 may possess the profile of a “metabolic regulator” capable of differentially modifying body weight and other parameters depending on the metabolic phenotype being treated

SOLANA BEACH, Calif., Sept. 16, 2026 (GLOBE NEWSWIRE) — Artelo Biosciences, Inc. (Nasdaq: ARTL) (“Artelo” or the “Company”), a clinical-stage pharmaceutical company focused on modulating lipid-signalling pathways to develop treatments for people living with cancer, obesity, pain, dermatologic, or neurological conditions, today announced remarkable results from a nonclinical study of ART27.13, its oral, once-daily, peripherally selective dual cannabinoid receptor agonist, in the diet-induced obesity model widely used to evaluate GLP-1 and other weight-loss medicines. In the study, ART27.13 administered alone produced weight loss comparable to semaglutide, and ART27.13 in combination with semaglutide approximately doubled the weight loss achieved with either agent alone.

Key Findings

• Weight loss comparable to semaglutide: In obese mice fed a high-fat diet, ART27.13 as a monotherapy reduced body weight from baseline by approximately 20% over four weeks – essentially mirroring the weight-loss curve of semaglutide.
• Doubling of weight loss in combination: Obese mice treated with both ART27.13 and semaglutide lost approximately 40% of their baseline body weight – twice the weight loss of either agent alone – bringing them to the body weight of lean, normal-weight animals.
• Weight lost was predominantly fat: Fat loss was greater in the ART27.13 treated groups (~80 % of the total weight loss was fat for both ART27.13 monotherapy or combination with semaglutide and ~70% with semaglutide monotherapy).
• Lean body mass and body fat were normalized to lean control animals by ART27.13 or semaglutide to similar extents, and the greatest effects were observed in the combination group of ART27.13 and semaglutide.
• No effect in lean control animals: ART27.13 had no effect on body weight, fat mass or lean mass in lean mice fed a standard diet. The weight-loss effect of ART27.13 appears to be specific to the obese state.
• Weight loss maintained as appetite recovered: Food consumption in treated obese animals declined initially and then recovered over the course of the study, while body weight remained at its reduced level.
• Metabolic parameters were favorable for ART27.13: Other markers of metabolic dysregulation (e.g. liver hypertrophy, cholesterol and glucose handling) were favourable for ART27.13 monotherapy, with the greatest effects shown in the combination with semaglutide.

The findings challenge a long-held assumption in obesity research. For more than two decades, the pharmaceutical industry’s approach to cannabinoid receptors in obesity has focused on blocking the CB₁ receptor with antagonists or inverse agonists. Full agonists such as ART27.13 which activate the receptors have largely been avoided. ART27.13 is a highly potent agonist of both the CB₁ and CB₂ receptors that is designed to act in the body’s peripheral tissues while minimizing effects in the brain. Its ability to produce weight and fat loss in obese animals therefore represents a new and differentiated pharmacology in the field.

“The prevailing dogma has been that CB₁ antagonism is required for weight loss, so observing semaglutide-like weight loss with a cannabinoid receptor agonist is striking,” observed Andrew Yates, Ph.D., Senior Vice President and Chief Scientific Officer of Artelo. “What makes these data especially compelling is the selectivity. In obese animals, ART27.13 drove substantial fat loss and improved body composition, while in lean animals there was no observed effect on weight, appetite or body composition. That is precisely the profile one would want in an obesity therapeutic.”

The results are consistent with independent, peer-reviewed research showing that both THC and synthetic cannabinoid receptor agonists can reduce body weight and fat in obese animals while having no effect on body weight or metabolic parameters in lean animals^1,2. The Artelo data extend those observations to a clinical-stage, orally administered small molecule, with an effect size comparable to the leading GLP-1 medicine.

“The consistency of these results across the initial pilot study and the follow-on study and in every measure we examined – body weight, food consumption, body composition and other metabolic parameters – is what gives us confidence in the signal,” said Professor Saoirse O’Sullivan, Ph.D., Vice President of Translational Science at Artelo. “In this nonclinical model, the doubling of weight loss in combination with semaglutide suggests that ART27.13 may work through a mechanism that is complementary to, rather than overlapping with, GLP-1 receptor agonism. Taken together, we believe the clinical and nonclinical data suggest ART27.13 may act as a peripheral metabolic regulator, promoting weight gain in a wasting state and weight loss in an obese state.”

“Based upon prior published research demonstrating ART27.13 ability to protect against cancer-induced skeletal muscle cachexia, we set out to answer a narrow question – whether ART27.13 could help protect muscle in patients taking GLP-1 medicines – and the study provided insight for a much bigger one,” added Gregory Gorgas, President and Chief Executive Officer of Artelo. “ART27.13 appears to have a profile that may fill a gap in weight-loss strategies. In the context of a global GLP-1 market that J.P. Morgan has projected could reach $200 billion by 2030, and an industry racing toward oral options and combination regimens, we believe these results warrant further investigation as to the role ART27.13 may play within one of the most important therapeutic categories in medicine. In addition to our ongoing partnering initiatives, this new data with ART27.13 is expected to open up new partnering conversations with pharmaceutical companies active in metabolic disease.”

About ART27.13
Initially developed by AstraZeneca plc, ART27.13 is a dual cannabinoid agonist that has been in over seven clinical studies with nearly 300 participants. It is being developed as a once-daily, orally administered agent selectively targeting peripheral CB₁ and CB₂ receptors, enabling systemic metabolic effects while minimizing central nervous system-mediated toxicity. Artelo is conducting a Phase 2 trial named the Cancer Appetite Recovery Study (CAReS) evaluating ART27.13 as a supportive care therapy for cancer patients suffering from anorexia and weight loss. Interim Phase 2 data revealed patients who had lost at least 5% of body weight to be included in CAReS and titrated to the highest ART27.13 dose (1300 µg) achieved an average +6% weight gain over 12 weeks, while patients on placebo lost an additional ~5%. Currently, there is no FDA approved treatment for cancer anorexia cachexia syndrome. In addition to CAReS, ART27.13 is also being evaluated in a Phase 2 study in people with glaucoma, called the DREAM study, investigating whether oral daily treatment can lower intraocular pressure.

About the Diet-Induced Obesity (DIO) Model
The DIO-2 study evaluated ART27.13 in mice with diet-induced obesity, the standard nonclinical model used across the industry to evaluate GLP-1 receptor agonists and other anti-obesity therapies. Obese mice maintained on a high-fat diet were treated with vehicle, semaglutide (20 nmol/kg) s.c., ART27.13 (2.5 µmol/kg) orally, or semaglutide in combination with ART27.13 under three dosing regimens. Lean mice maintained on standard chow were treated with vehicle or ART27.13 to assess effects in non-obese animals. Body weight and food consumption were measured throughout the four-week treatment period, and body composition was assessed by DEXA and MRI imaging. The findings replicate and extend the results of an initial pilot study (DIO-1) in the same model, in which co-treatment with ART27.13 was observed to improve the weight-loss efficacy when used in combination with semaglutide.

Ozempic^® and Wegovy^® are registered trademarks of Novo Nordisk A/S. Artelo Biosciences is not affiliated with, endorsed by, or sponsored by Novo Nordisk A/S.

About Artelo Biosciences
Artelo Biosciences, Inc. is a clinical-stage pharmaceutical company dedicated to the development and commercialization of proprietary therapeutics that modulate lipid-signaling pathways, with a diversified pipeline addressing significant unmet needs in obesity, anorexia, cancer, anxiety, dermatologic conditions, pain, and inflammation. Led by an experienced executive team collaborating with world-class researchers and technology partners, Artelo applies rigorous scientific, regulatory, and commercial expertise to maximize stakeholder value. More information is available at www.artelobio.com and X: @ArteloBio.

Forward-Looking Statements

This press release contains certain forward-looking statements within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934 and Private Securities Litigation Reform Act, as amended, including those relating to the Company’s product development, clinical and regulatory timelines, market opportunity, competitive position, possible or assumed future results of operations, business strategies, potential growth opportunities and other statements that are predictive in nature. These forward-looking statements are based on current expectations, estimates, forecasts and projections about the industry and markets in which we operate and management’s current beliefs and assumptions. These statements may be identified by the use of forward-looking expressions, including, but not limited to, “expect,” “anticipate,” “intend,” “plan,” “believe,” “estimate,” “potential,” “predict,” “project,” “should,” “would” and similar expressions and the negatives of those terms. These statements relate to future events or our financial performance and involve known and unknown risks, uncertainties, and other factors which may cause actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements. Such factors include those set forth in the Company’s filings with the Securities and Exchange Commission, including but not limited to: our ability to raise additional capital in the future; the inherent uncertainties of preclinical and clinical research, including the possibility that results observed in nonclinical animal models may not be predictive of, or replicated in, human clinical trials; the preliminary nature of the study results described in this press release, which remain subject to completion of the full analysis; the early stage of our obesity research program; the uncertainty of patent protection and the potential for intellectual property challenges; the highly competitive nature of the pharmaceutical industry, including the GLP-1, obesity and combination therapy markets; the risk that third-party market projections may not materialize or that the Company may not be able to participate in projected market opportunities; and our ability to enter into partnering or licensing arrangements on acceptable terms, or at all. Prospective investors are cautioned not to place undue reliance on such forward-looking statements, which speak only as of the date of this press release. The Company undertakes no obligation to publicly update any forward-looking statement, whether as a result of new information, future events or otherwise, except to the extent required by applicable securities laws.

Investor Relations Contact:
Crescendo Communications, LLC
Tel: 212-671-1020
Email: ARTL@crescendo-ir.com

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1 Avalos, B., Olmos, M., Wood, C.P., Alvarez, C., Read, H.M., Udompholkul, P., Garland, T., Jr and DiPatrizio, N.V. (2026), Δ9 Tetrahydrocannabinol and cannabis extracts differentially improve adipoinsular dysfunction in diet-induced obesity. J Physiol.
2 Verty AN, Stefanidis A, McAinch AJ, Hryciw DH, Oldfield B. (2015) Anti-Obesity Effect of the CB2 Receptor Agonist JWH-015 in Diet-Induced Obese Mice. PLoS One.