Month: September 2026

New geophysical interpretation indicates the Dumbwa Trend may extend northwest onto the adjacent 62 km² Mulundu Licence

VANCOUVER, British Columbia, Sept. 21, 2026 (GLOBE NEWSWIRE) — Midnight Sun Mining Corp. (TSXV: MMA / OTCQX: MDNGF) (“Midnight Sun” or the “Company”) is pleased to announce that it has entered into an Earn-In and Operating Agreement (the “Earn-In Agreement”) with Mulundu Holdings Limited regarding the 62 square kilometre Mulundu Licence (“Mulundu”), which is embedded within the Company’s Solwezi Project in Zambia. Recent geophysical interpretation indicates that the Dumbwa Trend may extend northwest from Midnight Sun’s existing licence area onto the Mulundu Licence. The Company intends to integrate Mulundu into its ongoing Dumbwa exploration program, with initial work focused on extending geophysical and geochemical datasets across the licence and identifying targets for drill testing.

Midnight Sun’s President & CEO, Al Fabbro, states: “Our recent geophysical work at Dumbwa has demonstrated a remarkable correlation with the known mineralized trend and, importantly, has informed a reinterpretation of the system as it continues north. The data suggests Dumbwa shifts to the northwest as it approaches the northern extent of the geochemical anomaly, potentially carrying the trend beyond our existing licence boundary and onto the neighbouring Mulundu Licence. When we recognized this, securing Mulundu became a clear priority. The acquisition of this licence has the potential to meaningfully expand our land-package and the footprint of Dumbwa.”

Terms of the Earn-In Agreement

The Earn-In Agreement consists of four stages:

Stage 1: Within one week of the date of the Earn-In Agreement, Midnight Sun will pay USD$25,000 to Mulundu Holdings Limited.

Stage 2: Midnight Sun will prepare and submit the required environmental documentation and obtain the applicable clearance from the Zambia Environmental Management Agency.

Stage 3: Within 24 months following completion of Stage 2, Midnight Sun may earn a 51% interest in the Mulundu Licence by sole-funding CAD$750,000 in exploration and development expenditures.

Stage 4: Following completion of Stage 3, Midnight Sun will have the right, but not the obligation, to earn an additional 29% interest, for an aggregate 80% interest in the Mulundu Licence, by sole-funding an additional CAD$3,000,000 in exploration and development expenditures within 36 months.

Once Midnight Sun has earned-in and completed sole-funding, the parties will form a joint venture entity to hold the Mulundu Licence. Each party will have the obligation to fund their proportionate interest, or face dilution as a result of a failure to participate. A party diluted to less than a 10% interest will have their interest converted to a 2% net smelter royalty (“NSR”). Midnight Sun may, at any time thereafter, elect to purchase the NSR upon payment of CAD$1 million to the holder of the NSR.

Qualified Person: Darin Labrenz, P.Geo., a consulting geologist for the Company and Qualified Person under NI 43-101, has reviewed and approved the technical data and contents of this release.

About Midnight Sun

Midnight Sun is rapidly advancing the Solwezi Copper Project, with a focus on our flagship Dumbwa copper deposit. The Project is located near the town of Solwezi in the heart of the Zambia–Congo Copperbelt, the world’s second-largest copper-producing region. This prolific mining district is renowned for hosting multiple major copper deposits, and benefits from excellent infrastructure, an established mining workforce, and a long history of successful production.

The Solwezi Copper Project is surrounded by producing copper mines, including the geologically similar Lumwana mine just west of our project and First Quantum’s Kansanshi mine – Africa’s largest integrated metallurgical processing facility, approximately six kilometres east of the company’s property boundary. This highly favourable location highlights the district-scale potential of Midnight Sun’s land package.

The Dumbwa copper deposit underlays a robust 20-kilometre copper-in-soil anomaly, and ongoing drilling has demonstrated strong geological similarities to the nearby Lumwana mine, underscoring the potential scale of this new copper system.

Led by an experienced geological team with a proven track record of major discoveries in the Zambia–Congo Copperbelt and globally, Midnight Sun’s goal is to delineate Zambia’s next generational copper deposit.

ON BEHALF OF THE BOARD OF MIDNIGHT SUN MINING CORP.

Al Fabbro
President & CEO

For Further Information Contact:
Adrian O’Brien
Director of Marketing and Communications
Tel: +1 604 809 6890
Em: adrian@midnightsunmining.com

NEITHER THE TSX VENTURE EXCHANGE NOR ITS REGULATION SERVICES PROVIDER (AS THAT TERM IS DEFINED IN THE POLICIES OF THE TSX VENTURE EXCHANGE) ACCEPTS RESPONSIBILITY FOR THE ADEQUACY OR ACCURACY OF THIS NEWS RELEASE.

This news release contains “forward-looking statements” within the meaning of the applicable Canadian securities legislation that are based on expectations, estimates, assumptions and projections as at the date of this news release. There is no guarantee of the Company completing any stage of the Earn-In Agreement, and, as such, any information in this news release regarding the timing of earn-in stages; expenditure amounts or work-product; the respective ownership interests of the Company in the licence; and any other information herein that is not a historical fact may be “forward looking statements”. Any statement that involves discussions with respect to predictions, expectations, beliefs, plans, projections, objectives, assumptions, future events or performance (which may, but not always, include phrases such as “anticipates”, “plans”, “scheduled”, “believed” or “intends” or variations of such words and phrases or stating that certain actions, events or results “may” or “could”, “would”, “might” or “will” be taken to occur or be achieved) are not statements of historical fact and may be forward-looking statements and are intended to identify forward-looking statements.

Although the forward-looking statements contained in this news release are based upon what management believes, or believed at the time, to be reasonable assumptions, the Company cannot assure readers that actual results will be consistent with such forward-looking statements, as there may be other factors that cause results not to be as anticipated, estimated or intended. Such factors include, among others, risks relating to the timing and ability to obtain the approval of relevant regulatory bodies, if at all; risks relating to property interests; risks related to access to the project; risks inherent in mineral exploration, including the fact that any particular phase of exploration may be unsuccessful; geo-political risks; the global economic climate; metal prices; environmental risks; political risks; and community and non-governmental actions. Neither the Company nor any other person assumes responsibility for the accuracy and completeness of any such forward-looking statements. The Company does not undertake, and assumes no obligation, to update or revise any such forward-looking statements or forward-looking information contained herein to reflect new events or circumstances, except as may be required by law.

A photo accompanying this announcement is available at https://www.globenewswire.com/NewsRoom/AttachmentNg/97907397-19a2-423b-8c0a-2df7c26a80ef

VANCOUVER, British Columbia, Sept. 21, 2026 (GLOBE NEWSWIRE) — Equinox Gold Corp. (TSX: EQX, NYSE American: EQX) (“Equinox Gold” or the “Company”) announces that it has elected to exercise its right to redeem all of its outstanding $172.5 million aggregate principal amount of 4.75% Convertible Senior Notes due October 15, 2028 (the “Notes”) (CUSIP No. 29446YAC0). All dollar amounts are in United States dollars.

The Notes were issued pursuant to an indenture dated as of September 21, 2023 (the “Indenture”) between the Company and Computershare Trust Company, N.A., as trustee. In accordance with the terms of the Indenture, on October 20, 2026 (the “Redemption Date”), the Company will redeem all Notes that have not been converted prior to 5:00 p.m., New York City time on October 19, 2026 (the “Conversion Deadline”).

Redemption Process

The redemption price for each Note will equal 100% of its outstanding principal amount, plus accrued and unpaid interest thereon to, but excluding, the Redemption Date (the “Redemption Price”). For each $1,000 principal amount of Notes, the Redemption Price will be equal to approximately $1,000.66. On the Redemption Date, the Redemption Price will become due and payable, and interest on the Notes will cease to accrue.

For all Notes in book-entry form, payment of the Redemption Price will be made through the facilities of the Depository Trust Company (“DTC”), and all such redeemed Notes will be surrendered for payment of the Redemption Price in accordance with the applicable rules and procedures of the DTC. The paying agent is Computershare Trust Company, N.A., and the address of the paying agent for delivery of any Notes in certificated form is Computershare Trust Company, N.A., 1505 Energy Park Drive, St. Paul, MN, USA 55108, Attention: Corporate Trust Operations.

Right to Convert the Notes

Holders of the Notes may convert all or any portion of their Notes (in a principal amount that is an integral multiple of $1,000) at any time prior to 5:00 p.m., New York City time on October 19, 2026 or, if the Company fails to pay the Redemption Price on the Redemption Date, until the date on which the Redemption Price is paid. To convert any Note, the holder must comply with the applicable rules and procedures of the DTC. As of September 18, 2026, the conversion rate under the Indenture is 158.7302 common shares of the Company (the “Common Shares”) per $1,000 principal amount of Notes. Such conversion rate will be adjusted to 165.0732 for any converting holder, representing a conversion price of approximately $6.0579, after giving effect to the applicable dividend adjustment and make-whole increase under the Indenture.

Based on this conversion rate, an aggregate of up to 28,475,124 Common Shares will be issued (representing approximately 2.44% of Common Shares outstanding) if all the Notes are converted.

This press release shall not constitute a notice of redemption or a notice of the right to convert the Notes. This press release is neither an offer to sell nor a solicitation of an offer to buy the Notes or any other securities and shall not constitute an offer to sell or a solicitation of an offer to buy, or a sale of, the Notes or any other securities in any jurisdiction in which such offer, solicitation or sale is unlawful. No representation is made as to the correctness or accuracy of the CUSIP number either as printed on the Notes or as contained in this press release.

About Equinox Gold

Equinox Gold (TSX: EQX, NYSE-A: EQX) is a Canadian mining company positioned as the new North American senior gold producer with a strong foundation of high-quality, long-life gold operations in Canada and across the Americas, and a pipeline of development and expansion projects. Guided by a seasoned leadership team with broad expertise, the Company is focused on disciplined execution, operational excellence and long-term value creation. Equinox Gold offers investors exposure to a diversified portfolio of gold operations, and clear path to growth. Learn more at www.equinoxgold.com or contact ir@equinoxgold.com.

Equinox Gold Contacts

Etienne Morin, Chief Capital Markets Officer

Ingrid Rico, SVP Capital Markets

E: ir@equinoxgold.com
T: +1 604.260.0516

Cautionary Notes & Forward-Looking Statements

This news release includes forward-looking information and forward-looking statements within the meaning of applicable securities laws and may include future-oriented financial information or financial outlook information (collectively “Forward-looking Information”). Actual results of operations and the ensuing financial results may vary materially from the amounts set out in any Forward-looking Information. Forward-looking Information in this news release includes: the Company’s redemption of the Notes, including the timing of, and payment of the redemption price on, the redemption date; the period during which holders of the Notes may elect to convert their Notes; and the conversion rate and conversion price applicable to the Notes, including as adjusted in connection with the redemption notice, and the resulting number of Common Shares issuable upon conversion of the Notes. Forward-looking Information is typically identified by words such as “believe”, “will”, “grow”, “plan”, “expect”, “estimate”, “advance”, “commence”, “continue” and similar terms, including variations like “may”, “could”, or “should”, or the negative connotation of such terms. While the Company believes these expectations are reasonable, they are not guarantees and undue reliance should not be placed on this Forward-Looking information. Forward-looking Information is based on the Company’s current expectations and assumptions. While the Company considers these assumptions reasonable, they may prove incorrect. Forward-looking Information involves numerous risks, uncertainties and other factors that may cause actual results and developments to differ materially from those expressed or implied by such Forward-looking Information. Such factors include certain risks and uncertainties described in the section “Risk Factors” in Equinox Gold’s Management Information Circular dated June 19, 2026, and in the section “Risks Related to the Business” in Equinox Gold’s most recently filed Annual Information Form, each of which is available on SEDAR+ at www.sedarplus.ca and on EDGAR at www.sec.gov/edgar. Forward-looking Information reflects management’s current expectations for future events and is subject to change. Except as required by applicable law, the Company assumes no obligation to update or to publicly announce the results of any change to any Forward-looking Information contained or incorporated by reference to reflect actual results, future events or developments, changes in assumptions or other factors affecting Forward-looking Information. If the Company updates any Forward-looking Information, no inference should be drawn that the Company will make additional updates with respect to those or other Forward-looking Information. All Forward-looking Information contained in this news release is expressly qualified by this cautionary statement.

VANCOUVER, British Columbia, Sept. 21, 2026 (GLOBE NEWSWIRE) — Miata Metals Corp. (TSXV: MMET; FSE: 8NQ; OTCQX: MMETF) (“Miata” or the “Company”) is pleased to announce metallurgical test results for samples collected from the Jons Trend corridor within the Company’s Sela Creek Gold Project in Suriname (“Sela Creek” or the “Project”).

Testing of four composite samples from drill core returned gold recoveries ranging from 91.8% to 98.5%, averaging 94.6%. The Company also announces that its sample preparation laboratory at the Sela Creek exploration camp is now operating and is ramping up to prepare all samples within the next month. Furthermore, founding director James Reid will assume the role of Executive Chair, effective October 1, 2026.

Highlights:

• 94.6% average gold recovery achieved from initial metallurgical testing of four Jons Trend composite drill core samples using combined gravity and 48-hour bottle roll leach processing
• Gold from the four Jons Trend composite samples is predominantly free-milling and non-refractory, allowing for conventional and straightforward processing
• On-site sample preparation laboratory with two industrial jaw crushers is now operating and is ramping up this month to process all Sela Creek drill core, channel and soil samples
• Sample preparation on site will reduce the sample size by ten-fold, with estimated assay laboratory savings of approximately US$10 per metre drilled, plus significantly lower shipping costs
• Founding director Mr. James Reid appointed Executive Chair, effective October 1, 2026

Dr. Jacob (Jaap) Verbaas, CEO of Miata, comments:

“These initial positive metallurgical results are highly encouraging for our main discovery zone Jons Trend. Recoveries averaging 94.6% and reaching up to 98.5% from four drill core composites using a proven, reliable and conventional approach to gold extraction, is a significant de-risking of the Sela Creek project. As drilling continues to expand Jons Trend, we continue to increase our understanding of the mineralization and how to ultimately recover the gold.

“We are also pleased to appoint James Reid as Executive Chair. James has helped guide Miata from its founding through the acquisition of our Suriname assets and the financings that have supported our progress. His expanded role strengthens our ability to align corporate strategy and capital allocation with the opportunities emerging at Sela Creek.”

Mr. James Reid, incoming Executive Chair of Miata, comments:

“I am excited to take on an expanded role as Miata enters its next stage of growth,” said Mr. Reid. “We have built a strong foundation at Sela Creek, and I look forward to working alongside Jaap, the Board and our team to build on that momentum and pursue opportunities that create long-term value for shareholders.”

Metallurgical Results — Jons Trend:

Initial metallurgical results yielded recoveries of up to 98.5% gold with an average recovery of 94.6%. The Company tested four composite drill core samples from Jons Trend. The composite samples contained sections of core from multiple drill holes and spanned a range between high- and low-grade gold within zones of shear veining and extensional veining. The core samples reflect the spatial variability as well as the variability in mineralization types, mineral assemblages and grade in Jons Trend. The submitted composite sample had lab grades of 8.22 g/t Au, 0.93 g/t Au, 2.03 g/t Au and 1.34 g/t Au. Gravity recoveries are slightly higher for high-grade extensional vein dominated gold occurrences, which likely contain a larger proportion of coarse-grained gold.

Gold was recovered using gravity separation followed by a 48-hour bottle roll leach. X-ray diffraction analysis indicates that all composites contained approximately 1 to 2 % sulphides in roughly equal amounts pyrite and pyrrhotite. Total organic carbon content is low and ranges from 0.03 % – 0.05 %, indicating very limited potential for preg-robbing. The results are very favourable and imply Jons Trend is amenable to standard-practice gold recovery circuits for orogenic gold systems. Subsequent testing to optimize grind size, reagent consumption and leaching kinetics is expected to further optimize recovery and processing cost.

Sample Preparation Laboratory Ramping Up to Full Scope:

The Company’s preparation laboratory is a facility at Sela Creek built to crush drill core, rock and channel samples. The preparation laboratory is now in use and will continue to ramp up to prepare all samples at Sela Creek within the next month. The preparation lab uses heavy-duty jaw-crushers to reduce regular half core samples to a fine crush, whereby at least 75% of the sample can pass a 2.2 mm screen. The uniformly crushed sample is then put through a riffle-splitter; resulting in a ca. 300-500 g sample, to be shipped to the Filab in Paramaribo for further sample prep and analysis, and the remaining reject is kept in dry storage for future quality control or duplicate testing. The on-site preparation laboratory reduces sample weight by ten-fold, and yields assay laboratory cost savings of approximately USD$10 per metre drilled. An additional cost saving comes from the reduced shipping weight of samples from site to the laboratory in Paramaribo, the capital of Suriname. The Company’s QAQC protocol for samples that are run through the prep lab has been adjusted with additional coarse crush duplicates.

Figure 1. Inside preparation laboratory at Sela Creek.

Appointment of James Reid as Executive Chair:

The Company is pleased to announce the appointment of James Reid as Executive Chair, effective October 1, 2026. Mr. Reid is a founding director of Miata and has been involved with the Company since its inception, including the acquisition of its Sela Creek and Nassau gold assets and over $50 million in financings.

As Executive Chair, Mr. Reid will chair the Board and support its governance responsibilities, while working with the CEO and senior management on corporate strategy, organizational structure and executive development. His responsibilities will also include supporting capital markets strategy, market positioning, capital allocation and financing initiatives; assisting in the evaluation and execution of strategic transactions and partnerships; and engaging with shareholders, investors and strategic counterparties to advance opportunities for shareholder value creation.

Mr. Reid is a Managing Partner at Three Peaks Capital, a Vancouver-based merchant bank focused on public and private company formation, financing and strategic transactions. He has extensive experience in corporate finance, capital markets and accounting, and has been involved in the formation, capital raising and asset acquisition strategies of numerous mining companies.

Mr. Reid previously worked at Haywood Securities Inc., where he served as a publishing research analyst covering Diversified Industries and Special Situations before moving into institutional sales. He also held an Investment Advisor role at the firm. His experience spans equity research, financial modelling, valuation, capital raising and transaction structuring. He holds the CPA designation and earned a Bachelor of Commerce from McGill University.

In connection with his appointment, the Company will grant an initial award of 1,683,331 performance share units (“PSUs”), representing 1% of the Company’s issued and outstanding common shares. The PSUs will vest only upon the occurrence of a change of control of the Company or the commencement of commercial production, aligning the equity component of Mr. Reid’s compensation with the achievement of significant long-term value creation milestones for shareholders. The award is intended to be maintained at 1% of the Company’s issued and outstanding common shares through annual PSU top-up grants.

The PSUs and any subsequent PSU grants will be issued under the Company’s 2026 Equity Incentive Plan, are subject to acceptance by the TSX Venture Exchange and applicable award agreements, and may not vest before the first anniversary of the applicable grant date.

QAQC

Composite samples selected for metallurgical testing were derived from one-quarter NQ diamond drill core. To ensure that the composites adequately reflected the spatial and lithological variability of the deposit, more than one composite sample was selected from specific drill holes to capture natural variations in head grade and mineral assemblages across the different zones. All analytical and testing work was performed by ALS, an independent, internationally recognized laboratory accredited under relevant ISO standards.

QP Statement

The scientific and technical information in this news release has been reviewed and approved for disclosure by Dr. Jacob Verbaas, P.Geo., a director of the Company and Qualified Person as defined under the definitions of National Instrument 43-101 – Standards of Disclosure for Mineral Projects.

About Miata Metals Corp.

Miata Metals Corp. (TSX.V: MMET) is a Canadian mineral exploration company listed on the TSX Venture Exchange, as well as the OTCQX (OTCQX: MMETF) and Frankfurt (FSE: 8NQ) Exchanges. The Company is focused on the acquisition, exploration, and development of mineral properties. The Company holds a 70% interest in the ~215 km² Sela Creek Gold Project with an option to acquire a full 100% interest in the Project, and a 70% beneficial interest in the Nassau Gold Project with an option to acquire 100%. Both exploration properties are located in the greenstone belt of Suriname.

On Behalf of the Board

Dr. Jacob (Jaap) Verbaas, P.Geo | CEO and Director

For Further Information, please contact:

Nikki McEachnie
Director of Investor Relations
nikki@miatametals.com
1-778-486-1500

Forward-Looking Statements

Certain information contained herein constitutes “forward-looking information” under Canadian securities legislation. Generally, forward-looking information can be identified by the use of forward-looking terminology such as “anticipates”, “anticipated”, “expected”, “intends”, “will” or variations of such words and phrases or statements that certain actions, events or results will occur. Forward-looking statements are based on the opinions and estimates of management as of the date such statements are made and are subject to known and unknown risks, uncertainties and other factors that may cause actual results to differ materially from those expressed or implied by such forward-looking statements or forward-looking information. Although management of the Company have attempted to identify important factors that could cause actual results to differ materially from those contained in forward-looking statements or forward-looking information, there may be other factors that cause results not to be as anticipated, estimated or intended. There can be no assurance that such statements will prove to be accurate, as actual results and future events could differ materially from those anticipated in such statements. Accordingly, readers should not place undue reliance on forward-looking statements and forward-looking information. The Company will not update any forward-looking statements or forward-looking information that are incorporated by reference herein, except as required by applicable securities laws.

Neither the TSX.V nor its Regulation Services Provider (as that term is defined in the policies of the TSXV) accepts responsibility for the adequacy or accuracy of this release

A photo accompanying this announcement is available at https://www.globenewswire.com/NewsRoom/AttachmentNg/b34aa8dc-f938-4a02-ba8d-8983bbdfb338

• CagriSema 1.0 mg/1.0 mg achieved superior weight loss of 12.4%* versus tirzepatide 5 mg of 9.1%* and non-inferior HbA_1c reduction at week 60 in adults with type 2 diabetes in REIMAGINE 5.
• CagriSema 1.0 mg/1.0 mg delivered significant and clinically meaningful weight loss of 21%* versus placebo at week 68 in adults living with overweight or obesity in REDEFINE 9. In both trials, CagriSema was well tolerated overall, with a safety profile consistent with previous studies.
  

Bagsværd, Denmark, 21 September 2026 – Novo Nordisk today announced topline results from the phase 3 REIMAGINE 5 and REDEFINE 9 trials of once-weekly CagriSema (cagrilintide and semaglutide), an investigational product, and Novo’s next innovation in weight management and type 2 diabetes. The findings were highlighted at Novo’s Capital Markets Day investor briefing.

In REIMAGINE 5, CagriSema 1.0 mg/1.0 mg was superior to tirzepatide 5 mg for weight loss, achieving an estimated average weight loss of 12.4%, compared with 9.1%, respectively. CagriSema also confirmed non-inferior reduction in HbA_1c (1.71%) versus tirzepatide (1.67%).

In REDEFINE 9, CagriSema 1.0 mg/1.0 mg provided a weight reduction of 21.0% versus 2.0% for placebo, and the primary superiority endpoint was met. CagriSema also showed greater improvements than placebo across prespecified supportive endpoints, including systolic blood pressure, waist-to-height ratio and fasting lipid profile.

“The results from CagriSema are very encouraging, demonstrating the strong potency of the combination of semaglutide and cagrilintide. With only 1.0 mg/1.0 mg, CagriSema shows superior weight loss versus tirzepatide 5 mg as well as strong results across obesity and type 2 diabetes,” said Martin Holst Lange, executive vice president, Research & Development and chief scientific officer at Novo. “CagriSema remains investigational, but these findings strengthen our confidence in its potential, add to the growing evidence for amylin biology and reinforce our ambition to advance the next generation of treatments for obesity and type 2 diabetes.”

Treatment decisions in obesity and type 2 diabetes are often individualised, and not all patients receive or remain on the highest available dose of current therapies. These data provide important evidence of the potential of CagriSema 1.0 mg/1.0 mg, and expand our understanding of how efficacy, tolerability and dose flexibility may support individualised care.

Also during Capital Markets Day, Novo presented data on painful diabetic neuropathy in type 2 diabetes for the first time, showing promising results. More details will be presented at a later time.

Trial key results

Trial	Population	Treatment	Primary Endpoints	Key Results
REIMAGINE 5	Adults with type 2 diabetes (inadequately controlled on metformin, SGLT2i, or both)	CagriSema 1.0 mg/1.0 mg vs. tirzepatide 5 mg	1) Change in HbA1c 2) Relative change in body weight (week 60)	Weight loss: 12.4% (CagriSema) vs. 9.1% (tirzepatide) – superior HbA1c reduction: 1.71% (CagriSema) vs. 1.67% (tirzepatide) – non-inferior
REDEFINE 9	Adults with overweight or obesity (adjunct to diet & exercise)	CagriSema 1.0 mg/1.0 mg vs. placebo	1) Relative change in body weight 2) Proportion achieving ≥5% weight reduction (week 68)	Weight loss: 21.0% (CagriSema) vs. 2.0% (Placebo) – superior

About the REIMAGINE 5 trial
REIMAGINE 5 was a phase 3 trial investigating once-weekly CagriSema 1.0 mg/1.0 mg compared with tirzepatide 5 mg in participants with type 2 diabetes inadequately controlled on metformin, an SGLT2 inhibitor or both. The dual primary endpoints were change in HbA_1c and relative change in body weight from baseline to week 60.

About the REDEFINE 9 trial
REDEFINE 9 was a phase 3 trial investigating once-weekly CagriSema 1.7 mg/1.7 mg and CagriSema 1.0 mg/1.0 mg compared with placebo, as an adjunct to a reduced-calorie diet and increased physical activity, in participants living with overweight or obesity. The primary endpoints were relative change in body weight and the proportion of participants achieving at least 5% body-weight reduction from baseline to week 68.

About CagriSema
Once-weekly subcutaneous CagriSema is being investigated by Novo as a treatment for adults with overweight or obesity (REDEFINE programme) and as a treatment for adults with type 2 diabetes (REIMAGINE programme). CagriSema is a fixed-dose combination of a long-acting amylin receptor agonist, cagrilintide, and a GLP-1 receptor agonist, semaglutide.

Novo filed a New Drug Application with the U.S. Food and Drug Administration in December 2025 for CagriSema for weight management, demonstrating the company’s commitment to lasting health innovation in obesity. A decision is expected in Q4 2026.

Novo is the global healthcare company that believes lasting health starts now. For over a century, we’ve combined leading scientific expertise with a deep understanding of people’s lives. We develop treatments and support that help millions of people make progress they can see, feel and sustain now and in the future. Every day, over 67,000 employees around the world advance our purpose to drive change for lasting health. Through our partnerships, programmes and investments, we’re working to prevent disease, expand access to treatments and reduce our environmental impact to help even more people live healthier lives. For more information, visit novonordisk.com and follow us on Instagram, LinkedIn, TikTok, Facebook, X and YouTube.

Contacts for further information

Novo Media:
Ambre James-Brown +45 3079 9289 globalmedia@novonordisk.com	Liz Skrbkova (US) +1 609 917 0632 USMediaRelations@novonordisk.com
Novo Investors:
Michael Novod +45 3075 6050 nvno@novonordisk.com	Sina Meyer +45 3079 6656 azey@novonordisk.com
Christoffer Togo Solgaard-Tullin +45 3079 1471 cftu@novonordisk.com
Ida Schaap Melvold +45 3077 5649 idmg@novonordisk.com	Mads Berner Bruun +45 3075 2936 mbbz@novonordisk.com
Frederik Taylor Pitter (US) +1 609 613 0568 fptr@novonordisk.com	Alex Bruce (US) +1 640 230 0276 axeu@novonordisk.com

_______________________
*Based on efficacy estimand

Attachment

• PR260921-CagriSema-CMD-2026