Month: September 2026

Flow Traders 3Q 2026 Pre-Close Call

Amsterdam, the Netherlands – Flow Traders Ltd. (Euronext: FLOW) publishes the 3Q 2026 pre-close call script to be used with analysts post the market close on 24 September 2026.

Welcome to the Flow Traders 3Q 2026 pre-close call, which is being conducted post the European market close on 24 September. During this call we will highlight relevant publicly available data and industry trends in our markets and relate these data points to their impact on our business for the quarter. The silent period for the second quarter starts on 1 October and we will publish our 3Q 2026 results on 29 October at 07:30 CEST.

Market Environment

ETF volumes in the third quarter decreased across most regions quarter-on-quarter¹, except for APAC. Geopolitical tensions in the Middle East and its macro-economic consequences continued, however volatility materially reduced. Average volatility, as indicated by the VIX, decreased by 13% on a quarter-to-date¹ basis.

In Digital Assets, there are strong segmental differences between bitcoin and altcoin markets versus tokenized RWAs. Crypto ETF volumes continue to be under pressure while the market for tokenized RWAs maintains its strong momentum.

Diving deeper into each of our businesses and regions:

Traditional

EMEA

In EMEA the third quarter showed lower ETF volumes when compared to the second quarter of 2026. The quarter-to-date¹ On and Off Exchange Value Traded in EMEA is 10% down compared to 2Q 2026.

APAC

In APAC ETF volumes paint a different picture compared to EMEA and the US. In the third quarter ETF volumes in APAC were up compared to the prior quarter. The quarter-to-date¹ On and Off Exchange Value Traded in APAC is 21% up compared to 2Q 2026. The quarter-to-date¹ On and Off Exchange Value Traded in China is up 22% compared to 2Q 2026. These data points reinforce the strong growth trajectory across the APAC region.

US

In the US the third quarter showed slightly lower ETF volumes when compared to the second quarter of 2026. The quarter-to-date¹ On and Off Exchange Value Traded in the US is 2% down compared to 2Q 2026.

Digital assets

Since 10 October 2025, the bitcoin and altcoin market has decreased materially with the market being more or less flat when compared to 2Q 2026 while materially down when compared to 3Q 2025. The quarter-to-date¹ EMEA crypto market ETF volumes are up 3% when compared to the same period in 2Q 2026 while volumes are down 62% compared to quarter-to-date 3Q 2025.

The market for tokenized RWAs showed continued strength during 3Q 2026. In 3Q 2026 the market size of this market increased to c. USD 39bn compared to c. USD 32bn in 2Q 2026, illustrating the strong continued momentum in that space².

Impact on Flow Traders

Coming to Flow Traders’ third quarter performance, the decreased market trading volumes and lower volatility in the third quarter are expected to result in significantly lower NTI compared to the second quarter. Fixed operating expenses for the quarter are in line with the cost guidance for 2026 of €235-245 million.

Contact Details

Flow Traders Ltd.

Investors

Dick Peters
Phone:         +31 20 7996799
Email:                investor.relations@flowtraders.com

Media

Eliza de Waard
Phone:         +31 20 7996799
Email:                press@flowtraders.com

About Flow Traders

Flow Traders is a leading global ETF and digital asset liquidity provider, on a mission to become the liquidity provider of choice in a 24/7 global financial ecosystem. Founded in 2004, Flow Traders has built on its heritage in European equity ETFs to provide liquidity across more than 25,000 products in ETFs, equities, fixed income, commodities, FX and digital assets, on over 150 venues globally. With more than EUR 7 trillion in annual value traded and over 1,600 active counterparties, Flow Traders plays a central role in ensuring markets remain resilient and transparent. The Company is investing in frontier technologies to drive innovation across traditional and digital asset markets. Operating from eight offices across Europe, the Americas and Asia, Flow Traders brings together over 600 professionals representing more than 60 nationalities.

Notes

1. Includes July and August
2. Source – RWA.xyz

Important Legal Information

This publication is prepared by Flow Traders Ltd. and is for information purposes only. It is not a recommendation to engage in investment activities and you must not rely on the content of this document when making any investment decisions. The information in this publication does not constitute legal, tax, or investment advice and is not to be regarded as investor marketing or marketing of any security or financial instrument, or as an offer to buy or sell, or as a solicitation of any offer to buy or sell, securities or financial instruments.

The information and materials contained in this publication are provided ‘as is’ and Flow Traders Ltd. or any of its affiliates (“Flow Traders”) do not warrant the accuracy, adequacy or completeness of the information and materials and expressly disclaim liability for any errors or omissions. This publication is not intended to be, and shall not constitute in any way a binding or legal agreement, or impose any legal obligation on Flow Traders. All intellectual property rights, including trademarks, are those of their respective owners. All rights reserved. All proprietary rights and interest in or connected with this publication shall vest in Flow Traders. No part of it may be redistributed or reproduced without the prior written permission of Flow Traders.

Flow Traders expressly disclaims any obligation or undertaking to update, review or revise any statements contained in this publication to reflect any change in events, conditions or circumstances on which such statements are based. Unless the source is otherwise stated, the market, economic and industry data in this publication constitute the estimates of our management, using underlying data from independent third parties. We have obtained market data and certain industry forecasts used in this publication from internal surveys, reports and studies, where appropriate, as well as market research, publicly available information and industry publications. The third party sources we have used generally state that the information they contain has been obtained from sources believed to be reliable but that the accuracy and completeness of such information is not guaranteed and that the projections they contain are based on a number of assumptions.

By accepting this publication you agree to the terms set out above. If you do not agree with the terms set out above please notify legal.amsterdam@nl.flowtraders.com immediately and delete or destroy this publication.

Market Abuse Regulation

This press release contains information within the meaning of Article 7(1) of the EU Market Abuse Regulation.

Attachment

• Flow Traders 3Q 2026 Pre-Close Call

Press release        Regulated information

Brussels, September 24, 2026, 17:45 CEST

In line with Belgian transparency legislation (Law of May 2, 2007), SIH Partners, LLLP recently sent to Solvay the following transparency notification indicating that they crossed the threshold of 3%.

Here is a summary of the notification:

Date on which the threshold is crossed	Voting rights after the transaction	Equivalent financial instruments after the transaction	Total
September 18, 2026	–	–	–

The notification, dated September 21, 2026, contains the following information:

• Reason for the notification:
  • Downward crossing of the lowest threshold
  • Update of a previous notification concerning financial instruments that are treated as voting securities
• Notified by: A parent undertaking or a controlling person
• Date on which the threshold is crossed: September 18, 2026
• Threshold crossed: 3% downwards
• Denominator: 105,876,416
• Additional information: Susquehanna International Securities Limited is able to rely on the trading book exemption. Once this exemption is applied, the position falls below the lowest disclosable threshold of 3%.
• Persons subject to the notification requirement: SIH Partners, LLLP, One Commerce Center 1201 N Orange Street Suite 715, Wilmington, Delaware, United States of America

Transparency notifications and the full chain of controlled undertakings through which the holding is effectively held are available on the Investor Relations Section of Solvay’s website.

Contacts

Investor relations

Geoffroy d’Oultremont: +32 478 88 32 96
Vincent Toussaint: +33 6 74 87 85 65
Charlotte Vandevenne: +32 471 68 01 66
investor.relations@solvay.com

Media relations

Peter Boelaert: +32 479 30 91 59
Laetitia Van Minnenbruggen: +32 484 65 30 47
media.relations@solvay.com

About Solvay

Solvay, a pioneering chemical company with a legacy rooted in founder Ernest Solvay’s pivotal innovations in the soda ash process, is dedicated to delivering essential solutions globally through its workforce of around 8,400 employees. Since 1863, Solvay harnesses the power of chemistry to create innovative, sustainable solutions that answer the world’s most essential needs such as purifying the air we breathe and the water we drink, preserving our food supplies, protecting our health and well-being, creating eco-friendly clothing, making the tires of our cars more sustainable and cleaning and protecting our homes. Solvay’s unwavering commitment drives the transition to a carbon-neutral future by 2050, underscoring its dedication to sustainability and a fair and just transition. As a world-leading company with €4.3 billion in net sales in 2025, Solvay is listed on Euronext Brussels and Paris (SOLB). For more information about Solvay, please visit solvay.com or follow Solvay on Linkedin. 

Ce communiqué de presse est également disponible en français.
Dit persbericht is ook in het Nederlands beschikbaar.

Attachments

• Press release
• 20260921 – Notification SIH Partners

Strasbourg, September 24, 2026, 5:45 pm CET

TRANSGENE (Paris: TNG) today announced that it has made available to the public and filed with the Autorité des marchés financiers its half-year financial report as of June 30, 2026.

The document is available on the Company’s website: www.transgene.fr, in the “Investors/Financial information” section.

This report comprises the following documents:

• 2026 half-year financial statements;
• Half-year management report;
• Statutory Auditors’ report on the 2026 half-year financial statements;
• Declaration by the person responsible for this half-year financial report.

Contacts

Media:  Caroline Tosch  Corporate and Scientific Communications Manager  +33 3 68 33 27 38  communication@transgene.fr

Investors & Analysts:

Lucie Larguier  Chief Financial Officer +33 3 88 27 91 00  investorrelations@transgene.fr

Attachment

• 20260924_Transgene_mise_a_dispo_HY1_EN

2026 Half-Year Financial Report

Attachment

• Transgene_HYR26_EN

2026 Half-Year Results and Business Update

myvac® – Expanding potential across solid tumors through viral vector, AI driven neoantigen selection, and scalable cell-line manufacturing

TG4050 – First Individualized Neoantigen Therapeutic Vaccine (INTV) from the myvac® platform advancing in resected HNSCC¹

• Randomized Phase 1 data published in Nature Communications; Sustained 100% disease-free survival (DFS) after more than 3 years of follow-up, showing durable clinical outcomes and potential to prevent cancer recurrence
• Randomized Phase 2 recruitment completed, trial is ongoing with topline results expected in Q1 2028
• Preparing for potential pivotal trial in HNSCC with cell-line manufacturing

TG4070 – Second novel myvac®-based INTV in early-stage NSCLC², with potential to be applied across multiple early-stage solid tumor types

• Leverages Transgene’s proprietary AI driven neoantigen selection (SNIPER^TM) and cell-line manufacturing
• All clinical sites open for randomized Phase 1 trial

Positive preclinical data from TG-MVA^TM, a new generation of prophylactic vaccine against mpox and smallpox based on MVA vector

Business funded until early 2028

Strasbourg, France, September 24, 2026, 5:45 pm CET — Transgene (Euronext Paris: TNG), a biotech company developing myvac®, an individualized neoantigen therapeutic vaccines (INTV) platform designed to prevent cancer recurrence and a portfolio of virus-based candidates, today publishes its financial results for the six months ended June 30, 2026, and provides an update on the progress of its pipeline and its upcoming plans.

“Since the beginning of the year, Transgene has delivered tangible progress and important results with the publication of the TG4050 Phase 1 data , the completion of enrolment in the Phase 2 trial in the same indication and the initiation  of the Phase 1 trial of TG4070, the second INTV from our myvac® platform introducing our proprietary AI-driven neoantigen selection and scalable cell-line manufacturing capabilities.” commented Alessandro Riva, MD, Chairman and Chief Executive Officer of Transgene.
“These milestones strengthen the foundation of the continued advancement of our myvac® platform, which will be key in our strategy to be Phase 3-ready in 2028, when we will obtain the topline results of the ongoing Phase 2 trial of TG4050 in resected head and neck cancer. At the same time, we are advancing our second INTV, TG4070, through Phase 1 development for non-small cell lung cancer.
“In parallel, we continue to leverage our expertise in MVA to develop TG-MVA^TM, a prophylactic vaccine against mpox and smallpox designed to address the growing global needs in biosecurity, pandemic preparedness and vaccine supply resilience. Supported by our financial visibility through early 2028, we are very well positioned to execute on our strategy and deliver the next wave of clinical and operational milestones for patients, partners and shareholders.”

TG4050: Data continue to support potential role in preventing cancer recurrence in HNSCC

Phase 1 part: Robust clinical proof of principle, with 100% DFS sustained after more than 3 years of follow-up – now published in leading peer-reviewed journal Nature Communications

At the end of August 2026, the comprehensive and compelling clinical and translational results from the Phase 1 part of Transgene’s randomized Phase 1/2 trial (NCT04183166) evaluating TG4050 in resected HNSCC (see press release) were published in Nature Communications. The peer-reviewed publication confirmed the positive clinical and translational findings, TG4050’s favorable safety profile and the persistence of durable neoantigen-specific CD8+ T-cell responses one year after the end of treatment.

Latest follow-up data, announced alongside the publication, demonstrate sustained 100% DFS in patients treated with TG4050 after more than 3 years of follow-up (41 months median follow-up), whereas 3 of 16 patients in the control arm have relapsed.

Phase 2 part: patient randomization completed

In April 2026, Transgene announced the completion of patient randomization in the Phase 2 part of the Phase 1/2 trial for the adjuvant treatment of HNSCC (see press release).

The primary objective of the Phase 1/2 trial is to compare TG4050’s efficacy as a single agent versus watchful waiting in patients with resected locoregionally advanced HPV-negative head and neck cancer, with 2-year DFS as the primary endpoint.

The emergence of immune checkpoint inhibitor (ICI)-based perioperative treatment marks an important advance in the HNSCC treatment landscape. However, a significant unmet medical need remains, with approximately 35% of patients still experiencing disease recurrence within two years. TG4050 is designed to further improve outcomes in this population by inducing durable, patient-specific anti-tumor immune responses with the potential to reduce the risk of relapse.

Transgene expects to communicate topline results from TG4050’s Phase 1/2 trial by the end of Q1 2028. First immunological data are expected to be available in H2 2026, with the goal of presenting them at a scientific conference in H1 2027.

Preparing future clinical development and potential pivotal clinical trial in HNSCC

In April 2026, Transgene and NEC Bio B.V. announced the signing of a license agreement to advance the clinical development of TG4050 in head and neck cancer (see press release).
Under this agreement, Transgene secures access to NEC’s AI-based neoantigen prediction platform, to support TG4050’s further clinical development, commercialization and potential partnering. Transgene has paid a technology access fee of €2.5 million in Transgene shares as well as €1.0 million of the additional €2.5 million cash payment, the remainder of which will be paid out in several instalments through early 2028. Additional development and milestone payments will be paid to NEC based upon progress of the clinical development of TG4050 in head and neck cancer. NEC retains full ownership and operational control of its AI platform and will support Transgene in conducting further clinical activity.

In parallel, Transgene is optimizing its manufacturing processes and capabilities to prepare for a potential pivotal clinical trial in HNSCC, including a transition of TG4050 to cell-line based manufacturing.

TG4070: Combining cutting-edge proprietary AI and scalable manufacturing to further expand the potential of the myvac® platform across multiple solid tumor indications

Initiation of a randomized Phase 1 trial for TG4070 in NSCLC

In June 2026, Transgene announced the initiation of a randomized Phase 1 trial evaluating TG4070, a novel INTV fully designed and developed in-house (see press release). Transgene’s second INTV candidate, TG4070, reflects the important strategic expansion of the myvac® platform. Like TG4050, it leverages Transgene’s clinically validated MVA viral vector, ensuring technological consistency of the myvac® platform.

Patient screening is underway in this multicenter trial. The study is evaluating TG4070 in combination with nivolumab in patients with resected NSCLC following neoadjuvant nivolumab plus chemotherapy (EUCT 2025-520946-31-00). The combination is designed to leverage the complementary potential of individualized vaccination and immune checkpoint inhibition to enhance and sustain patient-specific anti-tumor immune responses. Prof. Nicolas Girard, MD, PhD (Institut Curie) is the Principal Investigator. A replay of Transgene’s KOL event to discuss this new indication and the associated clinical trial is available here.

SNIPER^TM: Proprietary AI-based tool enabling high-precision neoantigen selection

Transgene has developed its proprietary in-house, AI-driven bioinformatics tool, SNIPER^TM, to support the development of TG4070 and future myvac®-derived candidates. Integrating multiple computational models, SNIPER^TM is designed to identify and prioritize highly immunogenic neoantigens for each individual patient through a proprietary scoring framework.
In addition, VacDesignR®, fully integrated into the myvac® platform, is Transgene’s patented in-house computational design engine that optimizes genetic constructs for MVA vectors, significantly improving production reliability and vector quality.

Cell-line optimized manufacturing to support large scale production for myvac® candidates

TG4070 is manufactured using a scalable and transposable cell-line based process designed to support broader deployment of INTV candidates while ensuring reliable vaccine supply. This optimized process enables more efficient and automated production, improved lead times and scalability. These manufacturing advances broaden the potential application of the myvac® platform across additional indications and larger patient populations.

Together, these proprietary capabilities provide Transgene with an integrated in-house technology suite spanning neoantigen selection, vaccine design and scalable manufacturing to support INTV development from candidate design through clinical development.

Transgene extends its pipeline with TG-MVA^TM, a prophylactic vaccine candidate against mpox and smallpox

Leveraging the investment already made in the MVA cell-line platform used for myvac®, Transgene is applying its deep viral-vector engineering expertise to Orthopoxvirus-related diseases, including mpox and smallpox.
TG-MVA^TM is a next generation vaccine candidate based on a non-replicating MVA backbone and an innovative cell line-based manufacturing process. It is designed to address key manufacturing and supply challenges, with the potential to diversify and expand vaccine availability to address public health needs and preparedness for future epidemics or bioterrorism threats.

On June 25, 2026, Transgene presented new preclinical data at the World Congress on Infectious Diseases (WCID) 2026, demonstrating the potential of TG-MVA^TM to provide robust protection against monkeypox virus (MPXV) (see presentation here).

Based on these positive results and ongoing discussions with Health Authorities and other key stakeholders on the next development steps, Transgene is preparing to advance TG-MVA^TM into clinical development to address future vaccine supply needs.

BT-001 oncolytic virus for intratumoral administration

The results obtained to date support the continued clinical development of BT-001 in solid tumors with the aim of improving responses to immunotherapy.
A Phase 1 clinical trial sponsored by an independent investigator at Copenhagen University Hospital has been approved by the Danish health authorities. Transgene and the University of Copenhagen are collaborating with the OV-PRIME-R trial to evaluate the combination of Transgene’s armed oncolytic virus BT-001 with an anti-PD1 in patients with localized rectal cancer with proficient mismatch repair status. Patient screening is expected to start in the coming months.

Governance: Anne Stehlin joins Transgene as Chief Quality Officer; Katell Bidet Huang appointed Interim Chief Scientific Officer

Anne Stehlin, PharmD, recently joined Transgene as Chief Quality Officer and Responsible Pharmacist. Reporting to Chairman and CEO Alessandro Riva, she is a member of the Executive Committee.
Dr. Stehlin is a pharmaceutical executive with extensive experience in quality and manufacturing operations. Prior to joining Transgene, she held senior global quality leadership roles at Lonza, a leading biopharmaceutical CDMO. Before that, she served as Head of Global Quality Management and a member of the extended management team at Basilea Pharmaceutica.
Earlier in her career, she held multiple leadership roles at Novartis across technical operations and product quality, eventually serving as Global Head of Product Quality Lifecycle Management.
Dr. Stehlin holds a PharmD degree from the University of Strasbourg.

Katell Bidet Huang, PhD, head of Translational Medicine at Transgene, has been appointed Interim Chief Scientific Officer (CSO), succeeding Maurizio Ceppi who has left the Company. In this role, she joins Transgene’s Executive Committee and will ensure continuity of the Company’s scientific activities and maintain momentum across its research and development programs. She will serve in this position until a permanent Chief Scientific Officer is appointed.

Key Financial Elements & Financial Visibility

(in thousands of euros)	June 30, 2026	June 30, 2025
Operating income	2,993	4,579
Research and development expenses	(15,425)	(17,910)
General and administrative expenses	(4,122)	(3,783)
Other expenses	(186)	54
Operating expenses	(19,733)	(21,639)
Operating income/(loss)	(16,740)	(17,060)
Financial income/(loss)	1,071	(2,235)
Net income/(loss)	(15,669)	(19,295)

Operating income amounted to €3.0 million for the first six months of 2026 compared to €4.6 million for the same period in 2025. It mainly consisted of the Research Tax Credit, amounting to €2.5 million, compared with €4.4 million for the same period in 2025.

As of June 30, 2026, Transgene had €92.8 million in cash, cash equivalents and other current financial assets, compared to €111.9 million as of December 31, 2025.

Transgene’s cash burn³ amounted to €20.3 million in the first half of 2026 compared with €18.8 million for the same period in 2025.

Under current plans, the company has sufficient cash to ensure financial visibility until early 2028.

The half-year financial report is available on Transgene website.

The Board of Directors of Transgene met on September 24, 2026, and closed the financial statements for the six-month period ended June 30, 2026. The Statutory Auditors have conducted a limited review of the interim consolidated financial statements.

***

Contacts

Transgene:
Media:	Investors & Analysts:
Caroline Tosch-Pourchot	Lucie Larguier
Corporate and Scientific Communications Manager	Chief Financial Officer (CFO)
+33 (0)3 68 33 27 38	+33 (0)3 88 27 91 00/21
communication@transgene.fr	investorrelations@transgene.fr
MEDiSTRAVA
Frazer Hall/Sylvie Berrebi
+ 44 (0)203 928 6900
transgene@medistrava.com

About Transgene
Transgene (Euronext: TNG) is a biotechnology company focused on designing and developing virus-based targeted immunotherapies and vaccines. The Company’s clinical-stage programs consist of a portfolio of viral vector-based immunotherapeutics. Transgene’s myvac® platform is designed to develop individualized neoantigen therapeutic vaccines (INTVs), with potential across multiple solid tumor types.
TG4050, the first INTV based on the myvac® platform is the Company’s lead asset, with demonstrated clinical proof of principle in the adjuvant treatment of head and neck cancer. TG4070, the second myvac®-based INTV introduces Transgene’s proprietary AI-driven neoantigen selection and scalable cell-line manufacturing capabilities and is in Phase 1 clinical development in combination with nivolumab in the adjuvant treatment of non-small cell lung cancer (NSCLC). The Company’s other viral vector-based assets include BT-001, an oncolytic virus based on the Invir.IO® viral backbone, which is in clinical development. Transgene also conducts innovative discovery and preclinical work, aimed at developing novel viral vector-based modalities.
With Transgene’s myvac® platform, therapeutic vaccination enters the field of precision medicine with an immunotherapy tailored to each individual patient. The myvac® approach enables the generation of virus-based immunotherapies encoding patient-specific neoantigens. Transgene has further expanded the platform’s capabilities with its own proprietary AI-driven neoantigen selection and scalable cell-line manufacturing.
Leveraging its MVA and cell-line manufacturing expertise, Transgene is developing TG-MVA™, a next-generation prophylactic vaccine candidate against mpox and smallpox designed to address key manufacturing and supply challenges.
With its proprietary Invir.IO® platform, Transgene is building on its viral vector engineering expertise to design a new generation of multifunctional oncolytic viruses.
Additional information about Transgene is available at: www.transgene.com
Follow us on social media: LinkedIn: @Transgene — X: @TransgeneSA — Bluesky: @Transgene

Disclaimer
This press release contains forward-looking statements, which are subject to numerous risks and uncertainties, which could cause actual results to differ materially from those anticipated. The occurrence of any of these risks could have a significant negative outcome for the Company’s activities, perspectives, financial situation, results, regulatory authorities’ agreement with development phases, and development. The Company’s ability to commercialize its products depends on but is not limited to the following factors: positive pre-clinical data may not be predictive of human clinical results, the success of clinical studies, the ability to obtain financing and/or partnerships for product manufacturing, development and commercialization, and marketing approval by government regulatory authorities. For a discussion of risks and uncertainties which could cause the Company’s actual results, financial condition, performance or achievements to differ from those contained in the forward-looking statements, please refer to the Risk Factors (“Facteurs de Risque”) section of the Universal Registration Document, available on the AMF website (http://www.amf-france.org) or on Transgene’s website (www.transgene.com). Forward-looking statements speak only as of the date on which they are made, and Transgene undertakes no obligation to update these forward-looking statements, even if new information becomes available in the future.

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¹ HNSCC: Head and Neck Squamous Cell Carcinoma

² NSCLC: Non-Small Cell Lung Cancer

³ Cash burn corresponds to the sum of net cash flows from operating, investing and financing activities, excluding proceeds from share issuances and excluding current account advance/other financial asset disposals related to the parent company. It does not include the effects of exchange rate fluctuations.

Attachment

• 20260924_HYR26_EN