SAN DIEGO, June 13, 2023 /3BL Media/ – The Corporate Eco Forum (CEF) presented the 2023 C.K. Prahalad Award to the First Movers Coalition, recognizing the coalition’s groundbreaking efforts to decarbonize high-emitting industries. The award was announced in connection with the 2023 CEF Annual Leadership Retreat, attended by senior executives representing CEF member companies with combined revenues of more than $5 trillion.

The First Movers Coalition, an initiative aiming to accelerate the race to net-zero, brings together cross-sector partnerships and collective action to address the decarbonization of seven major industries responsible for more than one-third of global carbon emissions. These hard-to-abate sectors, including aluminum, aviation, chemicals, cement and concrete, shipping, steel, and trucking, have proven challenging to decarbonize. Without urgent progress in clean technology innovation, there is concern their combined share of global emissions could surpass 50 percent by 2050.

“We are thrilled to honor the First Movers Coalition, and in particular the leadership of the US Special Envoy, John Kerry, and the World Economic Forum, with the 2023 C.K. Prahalad Award,” said MR Rangaswami, Founder of CEF. “Strong joint efforts such as this are needed to address the systemic and global nature of climate change and we’re proud that so many participating companies are CEF members including Amazon, Apple, Bank of America, Boeing, Delta Air Lines, Ecolab, Ford Motor Co., General Motors, Google, Microsoft, PepsiCo, Salesforce, Schneider Electric, and Trane Technologies.”

Launched in November 2021 by the Office of the US Special Presidential Envoy for Climate John Kerry and the World Economic Forum, the First Movers Coalition is a unique global public-private initiative. It has aligned and united a diverse range of players, leveraging the support of highly ambitious government partners representing over 40% of the global GDP. Collaborating with Canada, Denmark, India, Italy, Japan, Norway, Singapore, Sweden, the UAE, and the United Kingdom, the United States is leading the effort to create early markets for clean technologies through policy measures and private-sector engagement.

Recognizing the need for clean energy technologies that are not yet commercially competitive, the Coalition’s members commit to purchasing a portion of long-distance transportation services, and industrial materials such as aluminum, steel, and concrete, from suppliers utilizing near-zero or zero-carbon solutions, even if at a premium cost. Currently, more than 80 companies have made $12 billion in purchase commitments.

Each sector within the Coalition has established specific emission reduction goals. For instance, Coalition members in the aviation sector will replace at least 5% of conventional jet fuel demand with sustainable aviation fuels capable of reducing life-cycle greenhouse gas emissions by 85% or more compared to conventional jet fuels. Similarly, the shipping sector aims to power at least 5% of its deep-sea shipping with zero-emission fuels by 2030, with a target of 100% by 2040.

Furthermore, the Coalition has set ambitious commitments for companies to purchase durable and scalable carbon removal solutions by 2030, with Alphabet, Microsoft, and Salesforce leading the charge by committing a combined total of $500 million. To support its objectives, the Coalition collaborates with Breakthrough Energy, which brings together public and private partners to drive technology deployment, and Boston Consulting Group, the primary knowledge partner. Additionally, the Mission Possible Partnership mobilizes partners from leading organizations to design sectoral commitments and amplify impact through expertise and networking.

The urgency of the climate crisis demands a reduction of global greenhouse gas emissions by 50% by 2030 and achieving net-zero by mid-century, as determined by the latest climate science. The First Movers Coalition understands that disruptive clean technologies must be brought to the market at scale to achieve these targets. By sending a powerful demand signal, the Coalition is driving the development of technologies required for a more sustainable future.

World Economic Forum President Børge Brende added “The World Economic Forum gratefully accepts the esteemed C.K. Prahalad Award for the First Movers Coalition’s pioneering sustainability efforts. This recognition underscores our collective commitment to drive decarbonization in our global hard to abate industries. We extend sincere appreciation to our dedicated government partners and members for their instrumental collaboration in achieving this milestone, who are critical in accelerating the supply of innovative clean technologies.”

The C.K. Prahalad Award is bestowed in honor of renowned business strategist C.K. Prahalad, who emphasized the importance of business collaboration to tackle the challenges of our world. Prahalad believed that true collaboration goes beyond resource sharing and knowledge exchange, instead uncovering opportunities to “create new value that could not have been created alone.”

VIDEO: https://youtu.be/wYN9utTTq_s

ABOUT CEF

CEF is an invitation-only network of leading corporate executives driving sustainability strategy and innovation worldwide. Members include Fortune and Global 500 companies from diverse industries with combined revenues of over $5 trillion. CEF provides a year-round safe, neutral space for influential executives to exchange best practices, collaborate, and innovate. The diversity of executives, coupled with the cross-industry nature of CEF, creates a world-class platform to accelerate sustainable business problem-solving and innovation.

ABOUT THE C.K. PRAHALAD AWARD FOR FOR GLOBAL BUSINESS SUSTAINABILITY LEADERSHIP

The C.K. Prahalad Award for Global Business Sustainability Leadership, created in 2010 to honor founding CEF Advisory Board member C.K. Prahalad, recognizes exceptional, globally significant private-sector action that exemplifies the fundamental connection between sustainability, innovation and long-term business success in a globalizing world. Honorees may be either (1) individual executives, (2) notable corporate actions/initiatives, or (3) collaborations involving the private sector that have produced globally significant results. Winners are determined through private votes cast by CEF’s 24-member advisory board, which includes representatives from government, academia, nongovernmental organizations, and the private sector. The voters chose from a roster of finalists, selected following an open nomination process. Past award recipients include:

• 2010: Walmart Brazil CEO Hector Nuñez • 2011: Muhtar Kent, CEO, Coca-Cola • 2012: Neil Hawkins, Dow Chemical Corporate Vice President and CSO ; The Sustainable Apparel Coalition; Paul Polman, CEO, Unilever • 2013: Vidal Garza Cantú, Director, FEMSA Foundation; Hannah Jones, CSO and VP of the Innovation Accelerator, Nike; Kurt Kuehn, CFO, UPS • 2014: Robert B. Carter, CIO, FedEx Corporation; Global Water Challenge (GWC); Tamara “TJ” DiCaprio, Senior Director of Environmental Sustainability, Microsoft • 2015: David Crane, CEO, NRG Energy • 2016: Joe Kaeser, CEO, Siemens • 2017: Urs Hölzle, SVP for Technical Infrastructure, Google; Renewable Energy Buyers Alliance (REBA) • 2018: Lisa Jackson, VP for Environment, Policy and Social Initiatives, Apple; The Task Force on Climate-Related Financial Disclosures (TCFD) • 2019: TerraCycle’s Loop Shopping Platform; Posthumous honors to former Duke Energy CEO, Jim Rogers • 2020: Douglas M. Baker, Jr; Microsoft CEO Satya Nadella, President and Vice Chair Brad Smith, Chief Financial Officer Amy Hood, and Chief Environmental Officer Lucas Joppa • 2022: Shopify Sustainability Fund and Stripe Climate

CEF MEMBERS

3M, Amazon, Apple, Analog Devices, Aptiv, Archer Daniels Midland, ATI, Bank of America, BASF, Bill & Melinda Gates Foundation, BlackRock, Bloomberg, Boeing, CBRE, Chevron, Cisco, Cognizant, Comcast NBCUniversal, Dell Technologies, Delta Air Lines, Dow, Duke Energy, Ecolab, Enterprise Holdings, FEMSA, Fidelity, Ford, Four Seasons Hotels & Resorts, GE, General Motors, Google, GXO Logistics, Honeywell, HP, Hewlett Packard Enterprise, Hyatt, International Paper, Johnson & Johnson, JPMorgan Chase, Kaiser Permanente, Kimberly-Clark, Liberty Mutual, Lockheed Martin, Marriott International, Mastercard, McDonald’s, McKesson, McKinsey & Co., Meta, Microsoft, Morgan Stanley, NextEra Energy, Northrop Grumman, NRG Energy, Oracle, PepsiCo, Procter & Gamble, Qualcomm, RBC, Salesforce, Samsung, Schneider Electric, SEE, Siemens, SLB, Sylvamo, TD Bank Group, Tiffany & Co., TPG Capital, Trane Technologies, Unilever, UPS, Visa, The Walt Disney Company, Wells Fargo, WM

CNH Industrial Australia has announced a significant milestone, with the launch of its Reflect Reconciliation Action Plan (RAP), the first step in Reconciliation Australia’s RAP journey.

“The development of our first RAP is another step in our ongoing commitment to the expansion of the diversity of our workforce and commits us to relevant steps towards closing the gap on inequalities that remain for our First Nations peoples,” said Brandon Stannett, Managing Director, CNH Industrial, Australia and New Zealand.

“Through our RAP, we’re looking forward to more engagement with Aboriginal and Torres Strait Islander peoples, looking at ways we can assist with different activities and initiatives that help further their key objectives, and also work to highlight employment opportunities within our organization.”

Reconciliation Australia’s RAP framework provides organizations with a structured approach to supporting reconciliation within their workplaces and highlights practical plans for action within that business. There are currently four RAP levels that organizations can undertake as part of their reconciliation journey: Reflect, Innovate, Stretch and Elevate.

“We are so proud to have achieved the first RAP level and to begin implementing the actions within our Reflect RAP,” Brandon said.

Brandon said the RAP had been widely supported and accepted within the organization and staff were keen to get involved.

Part of the development of CNH Industrial’s Reflect RAP was the commissioning of an artwork by West Australian artist Taminga Connell, a Bunuba/Kija woman, descended from one of the Kimberley Region’s largest families. Together with her husband Scott, Taminga also operates Kimberley Spirit Tours, and the associated not-for-profit Kimberley Spirit Foundation, which aims to help reduce rates of youth suicide in the region, empowering and equipping children to reach their full potential.

The artwork Taminga created to mark CNH Industrial’s RAP is titled ‘Oneness’ which Taminga says represents “differing cultures and people coming together in unity so we can be whole”.

“It’s been a pleasure to work with Taminga to bring this piece of art to life, and now with the support of our staff and the global CNH Industrial leadership team, we start to turn our RAP commitments into meaningful actions that help benefit Indigenous communities and shape our own corporate culture,” Brandon said.

Almost one in five rail workers have suffered physical abuse at work, prompting Samaritans to urge the rail industry to invest in vital mental health support.

The suicide prevention charity released new research during Mental Health Awareness Week (May 15-21) which revealed two-thirds of rail staff had experienced negative changes in their mental health, compromising the ability to conduct their work.

The industry-wide mental health and wellbeing support survey, conducted by Samaritans and Mental Health at Work, highlighted more than half (57 percent) of rail workers continued working despite experiencing problems and 44 percent didn’t seek help.

Cost of mental health absences in workplace

Mental health-related absences have cost the sector more than £1.3bn since the start of 2019, and investing in staff mental health has proven to be cost-effective, with employers receiving an average return of £5 for every £1 spent on wellbeing support.

Great Western Railway (GWR) and the Department for Transport (DfT) funded the project which involved 1,773 respondents. An increase in passengers and the rising cost of living has contributed to staff requiring mental health support but as many as 65 percent admitted they didn’t seek support from their organisation as felt they couldn’t.

As pressure mounts within the industry amid rail strikes and delayed journeys, 61 percent of rail staff told the researchers they had faced verbal abuse from passengers, while 19 percent

While nearly a quarter of staff confessed they’d called in sick to their manager when their mental health was affected, others gave more promising feedback about how the industry was taking positive action by introducing mental health first aid training and providing platforms to connect with others who had experienced similar issues.

Help from Samaritans

The industry has received a set of recommendations for sustainable change from Samaritans – including more effective trauma support – to transform access to mental health in order to carve out a more inclusive culture and encourage staff to identify and discuss mental health at work.

Olivia Cayley, Head of Rail Programme at Samaritans, said: “This study highlights the range of barriers that rail staff experience when it comes to opening up about their mental health and seeking support that provides them with the right tools to feel better. “We want leaders in the rail industry to recognise that change needs to happen now, with investment into mental health and wellbeing support to better protect staff, so people have the help when they need it most.”

Ruth Busby, People and Transformation Director at GWR and Network Rail Wales and Western, said: “The wellbeing of our colleagues is so important, and this study is a further sign of our commitment to promoting an environment that supports positive mental health and colleagues experiencing trauma or mental illness.”

Peter Wilkinson, Managing Director of Passenger Services at DfT, said: “Given the enormous challenges all our staff and managers face every day on this busy and demanding railway, the wellbeing of our colleagues needs to be taken every bit as seriously as we do railway safety.”

Alison Pay, Manging Director of Mental Health At Work, said: “Investing in health and wellbeing should be a priority in any industry, but for the rail industry, where people are at the centre of the delivery, it is critical for success, safety and productivity, as well as the mental health of employees.

“This report has highlighted the key areas that very specifically impact mental health within the rail industry and the actions that can support employees moving forwards. It brings together the voice of the employee across all roles, alongside existing research and a review of the progress that has been made so far in this area. Implementing these changes at scale is inevitably challenging, but we now have a clear roadmap of the next steps and we hope that these compelling findings encourage all operators within this vital sector to begin the journey and make a difference to the working lives of the thousands of front line workers that keep both the country and the economy moving.”

Call 116 123 to speak to a Samaritan.

About Acre

At Acre, we work with the most aspirational businesses with potential to make real change; from those who are just starting out to those who are well on the journey to crafting a legacy.

Our 18 years’ experience in sustainability recruitment, combined with our extensive global network, enables us to provide talent solutions that are designed to deliver this change.

Through our unique behavioural assessment technology, we understand the types of people, skills and behaviours required to create impact. We can develop these qualities within your existing teams too.

We find talented people and develop their skills to ensure they make a true impact in ambitious, progressive organisations.

Acre. Making companies ready for tomorrow.

June 13, 2023 /3BL Media/ – Ceres President and CEO Mindy Lubber issued the following statement following the announcement of the Massachusetts Community Climate Bank. The innovative program, launched Tuesday by the administration of Gov. Maura Healey, is designed to unlock private and federal funds to accelerate the shift to zero-carbon buildings with a focus on affordable housing units.

“The launch of the Massachusetts Community Climate Bank is a tremendous example of the Commonwealth’s continued leadership in establishing ambitious climate policies that can serve as models for the nation,” Lubber said. “By using state funds to unlock substantial federal and private-sector resources, the Commonwealth is charting a novel form of public-private partnership to equitably address some of the most vexing challenges standing in the way of achieving its climate targets.”

Lubber is also a member of the Boston Green Ribbon Commission, a group of business and civic leaders working together to meet Boston’s climate goals that played an active role in supporting the development of the Community Climate Bank. She was invited to offer remarks at the Community Climate Bank’s announcement today. The full press release from the Healey administration can be read here.

Media Contact: Helen Booth-Tobin, booth-tobin@ceres.org, 617-247-0700 ext. 214

BELLEVUE, Wash. and MIAMI, June 8, 2023 /3BL Media/ –

What’s the news: HOPE Hydration (HOPE), maker of smart-city water refill stations, announced T-Mobile as the connectivity and IoT provider for its sustainable HydroStation® technology.

Why it matters: People are drinking more bottled water than ever and it’s taking a serious toll on our environment. So, HOPE is modernizing access to public drinking water to make clean, filtered water more sustainable and available.

Who it’s for: Event organizers, municipalities, or anyone looking to serve up free, clean, filtered water with minimal environmental impact.

Today, HOPE Hydration (HOPE), maker of smart-city water refill stations, announced T-Mobile (NASDAQ: TMUS) as its connectivity and IoT provider in the U.S. HOPE will rely on T-Mobile’s award-winning network and IoT solutions to offer an environmentally sustainable model for bringing free, filtered, and temperature-controlled drinking water to the masses at major events and urban hubs around the country.

According to the Container Recycling Institute, 86% of disposable water bottles used in the U.S. become litter or garbage ― adding 38 billion disposable water bottles to landfills. Joining forces with leading cities and partners, HOPE is on a mission to reduce waste and ensure that everyone around the world has equal access to free, high-quality drinking water. Winner of the CES 2023 Smart City Innovation Award, HOPE’s HydroStations dispense free Pentair1 Everpure® filtered and chilled water touch-free, to help reduce contaminants.

These tech-savvy water refill stations are dripping with innovation and the latest IoT technology ― and thanks to T-Mobile, HOPE can keep near real-time tabs on all their filling stations to:

Ensure proper water temperature and filter qualityMonitor usage and the amount of water dispensedCalculate the amount of plastic and carbon dioxide savedManage in-unit advertising displaysControl settings and scheduled maintenanceEnable partnering brands to track and achieve sponsorship and sustainability goalsDeliver critical over-the-air firmware and software updates

“HOPE Hydration is thrilled to work with T-Mobile as our connectivity and IoT provider.” said Jorge Richardson, Founder and CEO of HOPE Hydration. “We believe access to free, clean water is a human right. This collaboration allows us to bring HOPE, and our stations to the next level while building smart-city solutions for a more sustainable future.”

“We’re all about leveraging our network, scale and resources to be a force for good in the world we live in, and it’s clear that HOPE shares that passion,” said Callie Field, President, T-Mobile Business Group. “Access to clean, sustainable drinking water lies at the core of societal and environmental well-being — and we love how HOPE’s innovative HydroStation technology is creating more access while reducing environmental impact.”

To learn more about HOPE Hydration, visit: www.hopehydration.com

For more information about T-Mobile IoT, visit: https://www.t-mobile.com/business/solutions/iot

# # #

About HOPE Hydration

HOPE Hydration (“HOPE”) is a tech-enabled company that believes water is a human right. The company’s mission is to develop solutions to bring clean water without waste around the world through a technology solution-the HydroStation. HOPE is working to motivate new behaviors around water consumption, conservation, and waste-including reducing the environmental impact of plastics pollution. Brought together by a desire for a more sustainable future, HOPE’s team of co-founders – Dave Tigue, Cristina Gnecco and Ryan Barretta – have deep experience around sustainable development goals, business development, and software and hardware engineering. HOPE CEO Jorge Richardson, a Forbes 30 Under 30 Nominee, has collaborated with major Fortune 500 Brands on technology-powered hydration campaigns.

About T-Mobile US, Inc.

T-Mobile US, Inc. (NASDAQ: TMUS) is America’s supercharged Un-carrier, delivering an advanced 4G LTE and transformative nationwide 5G network that will offer reliable connectivity for all. T-Mobile’s customers benefit from its unmatched combination of value and quality, unwavering obsession with offering them the best possible service experience and undisputable drive for disruption that creates competition and innovation in wireless and beyond. Based in Bellevue, Wash., T-Mobile provides services through its subsidiaries and operates its flagship brands, T-Mobile and Metro by T-Mobile. For more information, visit: www.t-mobile.com.

Media Contacts

T-Mobile US Media Relations – MediaRelations@t-mobile.com

Investor Relations – investor.relations@t-mobile.com

HOPE Hydration Media Relations – katie@hopehydration.com 
 

1 All Pentair brands are trademarks of Pentair

NEW YORK June 13, 2023 /3BL Media/ – The Seleni Institute, a leading maternal mental health clinic and training institute, is pleased to announce the addition of new members to its advisory board from across the healthcare sector. Founded in 2011 by Nitzia and George Logothetis, Seleni is a recognized leader in treating, training, supporting and advocating for the emotional health of women, caregivers and their families during the family-building years. It does this through a unique hybrid approach that includes a maternal mental health practice, launched in 2013, serving individuals and families in the U.S., and through its accredited mental health training institute for healthcare practitioners around the world. Seleni was launched based on a simple yet powerful insight: Change a parent’s life, change a child’s life.

Seleni expands its advisory board amid a growing demand for the organization’s clinical services and training curriculum globally. Seleni reached a milestone of 50,000 patient appointments in 2022 and has trained more than 5,000 health professionals in 60 countries through in-person and online CE-accredited courses developed by Seleni clinicians, at times in partnership with other maternal mental health experts and institutions. Seleni’s advisory board members offer insights from their respective fields and support Seleni in its mission to raise greater global awareness around and address perinatal and reproductive mental health issues that affect tens of millions of families worldwide.

Seleni’s new advisory board members include:

Babalola Jinadu, DO, an obstetrician gynecologist with a special interest in women’s healthcare.Orinthia King, DO, an emergency medicine physician with a specialty in clinical ultrasonography.Sarah Mallin, MA, BSN, RNC-NIC, IBCLC, a former NICU nursing director, and founding member and director of operations at Boram Postnatal Retreat in New York.Renee M. Rawcliffe, LMSW, director of continuing education and professional development at Adelphi University School of Social Work. She is a licensed social worker with over 25 years of experience as a clinician and program director in the nonprofit world.Ashanda Saint Jean, MD, an obstetrician gynecologist with over 20 years of experience and chair of obstetrics and gynecology at Health Alliance Hospitals of the Hudson Valley.Susan Wilner, LCSW, assistant director for behavioral health operations at Stony Brook Medicine in New York.

They join their esteemed peers on the advisory board:

Deena Blanchard MD, MPH, a pediatrician in New York with a strong interest and commitment to maternal mental health.Lee S. Cohen, MD, director of the Ammon-Pinizzotto Center for Women’s Mental Health and Associate Chief of Psychiatry for Philanthropy and Departmental Communications at Massachusetts General Hospital, and the Edmund and Carroll Carpenter Professor of Psychiatry at Harvard Medical School. He is a leader in the field of women’s mental health and was among the founders of the field of perinatal and reproductive psychiatry.Phyllis Magrab, Ph.D., a pediatric psychologist and director of the Georgetown University Center for Child and Human Development (GUCCHD). She also holds a UNESCO Chair and serves as the vice chair of the US-Afghan Women’s Council.Ellen Manos, MD, an obstetrician gynecologist who has practiced for more than two decades. She serves as senior attending physician at Lenox Hill Hospital.

“Seleni’s advisory board has helped the organization become a leader in maternal mental health care over the past decade. As we look to expand our services beyond mental health during the family-building years and the reach of our continuing education program, we are excited to welcome these new board members who bring a wealth of expertise and new ideas that will help propel our growth over the next ten years,” said Seema Bajaj, executive director of Seleni.

Learn more about Seleni at seleni.org and see all advisory board member biographies at seleni.org/leadership-team.

About Seleni

Seleni is a nonprofit organization founded in 2011 on a simple yet powerful insight: Change a parent’s life, change a child’s life. As a recognized leader in maternal and reproductive mental health, Seleni is dedicated to destigmatizing maternal mental health care and supporting the emotional health of individuals and families during the family-building years. By removing many barriers to therapy through in-person and virtual treatment for individuals and couples and its CE-accredited training and scholarships for health professionals, Seleni helps scale access to treatment and expand practitioner knowledge worldwide. Visit seleni.org and explore the organization’s professional training curriculum at training.seleni.org.

Originally published by Ericsson

Did you know that extending cellular connectivity to the skies can save lives? Or enable sustainable transport for the future – and safe drone deliveries to your door? Join us as we explore digital airspace and all the opportunities this exciting new frontier of connectivity has to offer.

Cellular connectivity is almost everywhere these days – transforming the world around us, enabling everything from smart homes and the Internet of Things (IoT) to fully immersive virtual worlds. In fact, according to the most recent Network Coverage Outlook Mobility Report, 3GPP network coverage (that’s 3G and above) now serves roughly 95 percent of the world’s population, with 5G population coverage projected to reach 85 percent by 2028.

But although mobile coverage will soon cover the majority of human activities on the ground, there’s a vital dimension that has been left behind – a whole new frontier of opportunities, both for business and society. If we truly want to realize a future where limitless connectivity means limitless possibilities, we have to start looking in a new direction. Up.

You are now entering the exciting and elevated world of digital airspace.

What is digital airspace?

When we talk about digital airspace, we are talking about connectivity above the ground – whether that’s an altitude of 150 meters or 5,000 meters and beyond.

The mobile broadband technology we use today, although widespread and unmatched in its robustness and capabilities, was purposely developed and optimized to support users and services at the ground level – essentially, 2D use cases. To put it simply, our existing 3GPP network infrastructure simply wasn’t designed to provide coverage to direct cells and beam into free airspace.

At heights of only 50 meters, radio interference can become a major issue. At 150 meters and above, coverage becomes poor and unreliable. Both of these issues – interference and unreliable coverage – lead to lower bit speeds, higher latency and more connection interruptions. But how can we overcome them? And why is mobile broadband connectivity in the air important?

Imagine you’re a paramedic in an ambulance, transporting a patient in a critical condition to intensive care. In a situation where every minute counts, a rapid diagnosis from a specialist doctor could mean the difference between a life saved or lost. Fortunately, 5G connected ambulances can connect patients, ambulance workers and remote medical experts in real-time – not only through voice, but full high-definition video and haptic gloves, bringing zero-latency procedures to wherever they are needed.

But what if that patient was being air-lifted to safety, on a helicopter or aircraft? As our ground-based services move ahead, will our skies be left behind?

Digital airspace technologies – where are we now?

When it comes to the aviation industry, there are three prevalent conventional communications technologies, some of which have been in use for more than 50 years.

Very high frequency (VHF) radio

Common in civil aircraft communication systems, VHF is essentially a walkie-talkie voice system operating on a specific band spectrum, with fairly limited bandwidth and very limited capacity to send data.

Automatic Dependent Surveillance Broadcast(ADS-B)

ADS-B is a surveillance technology an aircraft can use to communicate its position to other aircraft and to air traffic management, with no data-sending capacity beyond basic details like the aircraft’s longitude, latitude, height, direction and speed.

Satellites

At high altitudes and in remote locations, satellite communication has been the only way to get some level of voice and data connectivity. Unsurprisingly, the use of geostationary (GEO) satellites (located high above Earth) comes at a very high cost – in bandwidth and latency as well as service costs. In recent years, we’ve also seen the emergence of low Earth orbit (LEO) satellites which require less power to transmit signals to the ground, provide lower latency for communications services and have lower service costs than their higher-orbit predecessors.

Now we understand some of the main conventional technologies operating in the digital airspace, let’s look at what role 3GPP technology can play – and why it provides a better option for meeting future airborne demands.

3GPP reaches new heights

Ericsson has been investigating the possibilities of reliable communication in the digital airspace for years, acknowledging the performance and additional capabilities such as data sending that 3GPP connectivity can offer – particularly for mission-critical communications, drone operations and management. Finally, we have reached a point where new technology is taking us to greater heights – and enabling brand-new services and revenue opportunities.

4G and 5G unlocking opportunities in the sky

How mission-critical mobile broadband solutions for the digital airspace are built will depend on the height above ground at which coverage is needed, as there are different demands depending on the altitude. It is important to consider horizontal and vertical aspects in handover and neighboring cell relation. Use case requirements on low latency and high data throughput with precise position accuracy must also be taken into account, as well as Doppler effect compensation for air vehicles with relatively high speed.

At low heights above the ground – below 300 meters – CSPs can generally leverage existing network infrastructure with some enhancements. However, at higher altitudes above 300 meters, interference issues and handover challenges become more of an issue, especially for high-speed use cases. Therefore, these typically require the use of an add-on dedicated sky network for coverage in the air, as well as uptilt antennas and high-resolution beam management.

One example of such a dedicated network is Teracom, a Swedish state-owned company that acquired radio spectrum and repurposed existing high mast radio tower infrastructure – originally built for radio broadcast – to offer air-ground-air coverage across the country. Featuring around 160 sites nationwide, with an average antenna height of 150 meters and some reaching up to 300 meters (powered by Ericsson 5G-ready Massive MIMO), the network has successfully delivered coverage for altitudes up to 5000 meters and above.

The mission-critical coverage and data-sharing capabilities this network enabled have already shown great value and potential. This is the most mature digital airspace market area, where opportunities already exist today – and the first of two we will dive into in more detail here.

Mission-critical communication use cases: opportunities await

When it comes to public safety operations, real-time information, efficiency and safety are all vital. In one use case tested in the trial with Teracom, an emergency call was simulated, reporting the presence of a fire somewhere in the forest area. Traditionally, for this type of emergency call, responders would be sent out in a vehicle to conduct an inspection and decide what resources are needed and how many people need dispatching.

With 3GPP coverage, they were able to immediately send out a drone equipped with multiple sensors for wind speed, temperature and location, as well as with a video and infrared camera, which could send back high-quality video of the scene in real-time, as well as data on the environmental conditions. With 5G connectivity, drones can be used beyond visual line of sight to perform fire inspection tasks and send back data for better decision-making, such as the type and volume of resources required for firefighting.

While mission-critical areas such as public safety, search and rescue operations and the maintenance of utilities and infrastructure like railroads would all clearly benefit from these technologies, the opportunities also extend much further. We already touched on the possibilities for healthcare – drones for mission-critical healthcare applications can save lives, not to mention our example of enabling the connected ambulance use case to truly take flight. Sectors such as agriculture, mining, oil and gas, construction and real estate, and even our own telecoms industry also have a lot to gain from smart site monitoring and maintenance.

The drones are here: are we ready?

According to Grand View Research, the global commercial drone market was estimated at USD 29.86 billion in 2022, and is predicted to grow at a compound annual growth rate of 38.6 percent from 2023 to 2030. Industries are increasingly looking to use drones for a wide range of purposes:

Agriculture

Drones equipped with sensors and cameras can be used to monitor crop health, detect nutrient deficiencies, and identify pests and diseases. This can help farmers optimize their use of pesticides, fertilizers and water, increase crop yields and contribute to wildlife protection or control.

Construction

Drones can be used to conduct site surveys, monitor construction progress, and inspect buildings and infrastructure. This can help contractors identify issues early on and reduce the need for costly manual inspections.

Energy

Drones can be used to inspect power lines, wind turbines and solar panels, as well as monitor oil and gas pipelines instead of using more costly helicopters. This can help energy companies identify and fix problems more quickly, lower costs and reduce the risk of accidents.

Logistics

Drones can be used to automate delivery of packages and goods making delivery quicker, more efficient and more sustainable. This can be especially useful in remote or hard-to-reach areas but also in urban and suburban areas with a lot of road traffic.

Mining

Drones can be used to survey mine sites and monitor stockpiles, as well as to inspect equipment and infrastructure. This can help mining companies reduce costs, improve safety, and increase productivity.

Mission-critical and mass-market parcel delivery will relieve the need for ground vehicle transport, reducing road traffic and emissions for a more sustainable solution. Meanwhile, mobility infrastructure and services in metropolitan areas are already at their limits. A range of solutions are already emerging on the road to autonomous transportation. Public transport, active mobility, self-driving vehicles and ride-sharing services will be vital to address these challenges and provide more efficient, sustainable and equitable transportation options.

Innovative new solutions are soon to follow, with trends already suggesting that pre-commercial piloted air taxis are likely to emerge in the next two to three years. Today drones may be collecting data – but tomorrow they will be moving goods, and in the future, they will be moving us.

The capabilities necessary for many of these use cases have already been demonstrated utilizing 5G networks, like TDC and Ericsson’s collaborative pilot and subsequent tests summarized in a GSMA Foundry case study from last year.

The role of 3GPP

As discussed in an earlier blog post on the Internet of Drones, 3GPP research projects dating back to 2016 have explored the feasibility of using existing LTE networks to provide connectivity to low-altitude drones. These have also acknowledged the challenges related to interference as well as mobility – particularly as the density of drones, or unmanned aerial vehicles (UAVs), increases.

The availability of radio frequency spectrum resources also plays a critical factor in enabling reliable communication services to UAVs. Most drones today use unlicensed spectrum, which will not be sufficient going forward as new use cases emerge and the volume of drones increases. It’s also important to note that the spectrum situation differs from country to country, and some countries still lack regulation in this area.

Despite this, 3GPP connectivity offers a wide range of benefits for UAVs that are not possible with the existing communications technologies – not least of which is enabling real-time data-sharing and constant connectivity. Network exposure application programming interfaces (APIs) will enable dynamic control of quality of service (QoS), drone identification, drone location tracking, 3D coverage maps and geographic SIM density – all of which will result in improved safety, efficiency and cost savings for the aviation industry.

The use of 3GPP APIs will also open up new opportunities for innovation and collaboration between aviation and mobile network industries, leading to the development of new products and services that can further enhance the digital airspace ecosystem. Ericsson Drone Mobility has successfully demonstrated how some of the telecom APIs like QoS and SIM density can be leveraged to make drone flights safe and secure.

Ericsson subsidiary Vonage, a leading Communication-Platform-as-a-Service (CPaaS) and aggregator of network APIs, is already working with mobile network operators and application service providers to help make 5G-enabled APIs like Location, QoS on Demand, Security and other network-aware APIs available that can be used by the aviation and drone industry on a global scale.

But to realize the full potential of UAV technologies, we must first solve the challenges that large quantities of aircraft will pose to air traffic management (ATM), and more specifically, how the requirements of UAV traffic management (UTM) can be met, both now and in the years to come.

Airspace management: the major future use cases start now

Today, ATM is still a fully manual process. A pilot will contact air traffic control by VHF radio and be guided where and when they can land. But if we introduce UAVs to the mix, things get more complicated. In the near future, a drone user will need to send a request to the UTM in advance, stating their intended departure and arrival locations, and be given a route and timeslot they must use. With existing or other new proprietary technologies enabling command and control connectivity, the drones could perhaps communicate the necessary information to a unified ATM/UTM.

But as the volume of drones continues to grow (as it will), and shared airspace means full synergy with ATM becomes a necessity, full, highly-automated integration with UTM will be needed. Automation and artificial intelligence will be an absolute must for safe overall traffic management, including monitoring where all the aircraft and drones are, where they are going, and what happens if something goes wrong.

Ready, steady, go: the drone race is on

The global race towards drone readiness has just begun, but the European Union is well-positioned with a clear roadmap. Regulatory frameworks have been put in place to ensure a safe and smooth introduction of UAVs in harmony with aviation, including requirements for UTM.

According to the vision outlined in the European Drone Strategy 2.0, “by 2030 drones and their required eco-system will have become an accepted part of the life of EU citizens,” by which time they expect the current U-space regulatory framework (and therefore high-capacity UTM) to have been completely rolled out in the EU, and that “additional advanced U-space services will support large scale highly automated and digitally connected affordable, safe, secure, and environmentally friendly unmanned aircraft operations in several Member States.”

From January 2023, EU regulations (called U2) permit drone operation beyond visual line of sight (BVLOS), which requires permanent connectivity between the drone and the remote operator. Today, if a drone loses position data or the quality of its control signal, it will enter emergency mode in a few seconds and make an emergency landing. If a drone doesn’t know where it is, or what to do, then that drone needs to go down, fast.

As Ericsson Drone Mobility demonstrated in the 5G Innovation Hub together with TDC NET, 3GPP networks can not only help ensure reliable connectivity but can also, for example, provide SIM density information to a UTM system, enabling a better understanding of ground population movements to determine the ground risks below.

5G networks can be of particular benefit for BVLOS flights. For UAVs to fly in the same space as other aviation traffic, we need to know that it must be at least as safe – if not more – than in traditional aviation. Fully automated UTM systems and permanent connectivity for BVLOS UAVs (requiring mobile broadband connectivity) will be vital for ensuring that high volumes of vehicles in the air at the same time can be managed to a very high security level.

With the aviation industry in transformation, a new scalable approach to communication and ATM is needed. With 5G, we’ll be able to leverage new technologies like beam forming (directing the radio energy in a particular direction – like at an aircraft, even moving at speed), enabling efficient, reliable coverage ready to meet these new use cases. Naturally, this development will require a great deal of work and support. To us, it’s clear that high-performance 3D radio networks with predictable coverage and capabilities will offer the best solution for enabling advanced automated drone applications, and for a safer, smarter and more sustainable digital airspace.

That is why we’re already developing the key technologies, products and services to make operators and enterprises succeed in monetizing the digital airspace, as well as engaging with the broader ecosystem to understand the requirements. We’re also driving 3GPP standardization beyond traditional mobile broadband, to provide comprehensive solutions for the modern aviation industry.

How will you take advantage of the open skies?

Digital airspace offers a perfect example of a new potential cellular ecosystem – and an excellent 5G use case – that CSPs can monetize. The next question is, what role will you play?

Will you just provide 3GPP connectivity for air use cases, or will you go further? Will you expose high-value information from the network and capabilities to enable new services? Will you partner with governments or other operators investing in mission-critical infrastructure, or provide drone management services for the exciting UAV commercial use cases to come? Can you help support countries’ future needs when it comes to ATM and UTM systems?

Whatever opportunities you choose to take, you need to act now to ensure you don’t miss out. Start thinking about your strategy, because when it comes to digital airspace, the sky is the limit.

Learn more

Read the case study detailing Teracom and Ericsson’s trials of 5G-ready air-ground-air connectivity for mission-critical airborne operations.

Find out more about how Ericsson drone mobility is enabling the digital airspace.

Explore the future of connected aviation, and the runway leading us there, in our recent blog post.

Ada Lopez, Senior Manager, Global Product Diversity Office, Lenovo

The past year has seen artificial intelligence (AI) become a dinner-table topic of conversation around the world, thanks to bots such as ChatGPT, which dazzles users with its ability to compose lifelike text and even computer code. But what happens when AI makes wrong decisions?

It’s a serious issue. Bias – and gender bias in particular – is common in AI systems, leading to a variety of harms, from discrimination and reduced transparency, to security and privacy issues. In the worst cases, wrong AI decisions could damage careers and even cost lives. Without dealing with AI’s bias problem, we risk an imbalanced future – one in which AI will never reach its full potential as a tool for the greater good.

AI is only as good as the data sets it is trained on. Much data is skewed towards men, as is the language used in everything from online news articles to books. Research shows that training AI on Google News data leads to associating men with roles such as ‘captain’ and ‘financier’, whereas women are associated with ‘receptionist’ and ‘homemaker’.

As a result, many AI systems, trained on such biased data and often created by largely male teams, have had significant problems with women, from credit card companies which seem to offer more generous credit to men, to tools screening for everything from COVID to liver disease. These are areas where wrong decisions can damage people’s financial or physical health.

This is compounded by the fact that just 22% of professionals in AI and data science are women, according to the World Economic Forum’s research. Gender itself is also becoming a more complex topic, thanks to non-binary and transgender expressions, leading to more potential for bias in many different forms.

AI is a powerful tool that offers us the chance to solve previously unsolvable problems from cancer to climate change – but unless the bias issue is addressed, AI risks being untrustworthy, and ultimately irrelevant. If AI professionals cannot confront the bias issue, these tools will not be useful, and the artificial intelligence industry risks another ‘AI Winter’, as seen in the 1970s, when interest in the technology dried up.

Dealing with data

Going forward, businesses will increasingly rely on AI technology to turn their data into value. According to Lenovo’s Data for Humanity report, 88% of business leaders say that AI technology will be an important factor in helping their organisation unlock the value of its data over the next five years.

So how will business leaders deal with the problem of bias? For the first time in history, we have this powerful technology that is entirely created from our own understanding of the world. AI is a mirror that we hold up to ourselves. We shouldn’t be shocked by what we see in this mirror. Instead, we should use this knowledge to change the way we do things. That starts with ensuring that the way our organisations work is fair in terms of gender representation and inclusion – but also by paying attention to how data is collected and used.

Whenever you start collecting data, processing it, or using it, you risk inserting bias. Bias can creep in anywhere: if there is more data for one gender, for example, or if questions were written by men.

For business leaders, thinking about where data comes from, how it’s used, and how bias can be combatted will become increasingly important.

Technical solutions will also play an important part. Data scientists don’t have the luxury of going through every line of text used in a training model.

There are two solutions to this: one is having many more people to test the model and spot problems. But the better solution is to have more efficient tools to find bias, either in the data which the AI is fed with, or in the model itself. With ChatGPT, for example, the researchers use a mental learning model to annotate potentially problematic data. The AI community needs to focus on this. Tools to provide greater transparency in the way AI works will also be important.

Understanding bias

It also helps if we consider the broader context. The tools we use today are already creating bias in the models we will apply in the future. We might think that we have ‘solved’ a bias issue now, but in 50 years, for example, new tools or pieces of evidence might change completely how we look at certain things. This was the case with the history of Rett syndrome diagnosis, where data was primarily collected from girls. The lack of data on boys with the disorder introduced bias into data modelling several years later and led to inaccurate diagnoses and treatment recommendations for boys.

Similarly, in 100 years, humans might work for only three days a week. That would mean that data from now is skewed towards a five-day way of looking at things. Data scientists and business leaders must take context into account. Understanding social context is equally important for businesses operating in multiple territories today.

Mastering such issues will be one of the touchstones of responsible AI. For business leaders using AI technology, being conscious of these issues will grow in importance, along with public and regulatory interest. By next year, 60% of AI providers will offer a means to deal with possible harm caused by the technology alongside the tech itself, according to Gartner.

Business leaders must plan thoroughly for responsible AI and create their own definition of what this means for their organisation, by identifying the risks and assessing where bias can creep in. They need to engage with stakeholders to understand potential problems and distinguish how to move forward with best practices. Using AI responsibly will be a long journey, and one that will require constant attention from leadership.

The rewards of using AI responsibly, and rooting out bias wherever it creeps in, will be considerable, allowing business leaders to improve their reputation for trust, fairness and accountability, while delivering real value to their organisation, to customers and to society as a whole.

Businesses need to deal with this at board level to ensure bias is dealt with and AI is used responsibly across the whole organisation. This could include launching their own Responsible AI board to ensure that all AI applications are evaluated for bias and other problems. Leaders also need to address the broader problem of women in STEM, particularly in data science. Women – especially those in leadership roles – will be central to solving the issue of gender bias in AI.

An AI-driven future

Understanding the problem of gender bias and working towards effective ways of dealing with it will be vitally important to forward-thinking organisations hoping to use AI to unlock the value of their data.

Thinking carefully about how AI is used across an organisation, using tools to detect bias and ensure transparency, will help. But business leaders also need to take a broader view of where their data comes from, how it is used, and what steps are being taken to avoid bias. Doing so will be essential to unlocking the value of their data – and creating an inclusive future where AI can work to its fullest potential.

June 13, 2023 /3BL Media/ – The Ray has implemented a regional staff strategy for accelerating net-zero transportation nationally. To better support net-zero projects at transportation agencies and accelerate project delivery by reducing the time required for planning and procurement, dedicated regional staff teams will work from satellite offices distributed among four U.S. regions: Northeast, Southeast, Midwest, and West. The strategy will be effective immediately, as The Ray currently works with more than 51 transportation agencies at the local, state, and regional levels across 29 states to scale infrastructure projects that will produce safer, cleaner and smarter outcomes in the transportation and energy sectors. The Arthur M. Blank Family Foundation awarded The Ray a $250,000 grant to support the launch of the regional strategy and, more broadly, the innovative planning and solutions that The Ray deploys in the Southeast to make renewable energy and electrification accessible and more affordable.

The Ray has pioneered technology applications and net-zero project concepts in transportation and energy for nearly a decade,” said Allie Kelly, Executive Director of The Ray, “and those ideas and our know-how have met the moment of tremendous opportunity.” She continued, “Across the country, state agencies and communities alike have an urgency for infrastructure that we can help them build, projects such as roadside solar; smart highway systems that are safer and less congested; longer-lasting, quieter roads paved with scrap tire rubber, and using empty transportation ‘right-of-way’ for expanding and securing the energy grid, instead of stringing new wires across neighborhoods.”

As an organization with a national reach, grouping partner activity by region and distributing the pipeline of projects and analyses between regional teams at The Ray creates process efficiencies that produce faster results for transportation agencies – helping the agencies themselves to go faster. Regional coordination of agency partner activity also facilitates the visibility and viability of opportunities for multi-state collaboration. The Ray provides:

Technology transferConnections to private sector 
technologists and expertsConnections to peer transportation 
agenciesAdvanced planning tools and softwareTechnical assistanceProcurement assistanceProject organization and facilitationPolicy analysisPublic awareness and promotion

National Presence 
These services directly address the gaps and challenges facing transportation agencies with expertise, tools, analysis, collaboration, and, indirectly, by building confidence in and enthusiasm for innovation. In both formal and informal collaborative partnerships, The Ray continues to promote and scale net-zero infrastructure that will support decarbonizing transportation and enable the safe operation of connected and autonomous vehicles.

Net-Zero Projects 
The Ray’s mission is to reimagine how advanced transportation infrastructure and technology connects communities, lives, and the world in a way that is safer, more responsive to the climate, more regenerative to the environment, and more capable of creating economic opportunity through innovative ideas and technologies that will transform transportation infrastructure. At The Ray C. Anderson Memorial Highway on Interstate 85 in West Georgia, The Ray is catalyzing net-zero transportation infrastructure on a real-world test bed – zero carbon, zero waste, zero deaths. Leading the way with some of the world’s boldest thinking, The Ray has built more than a dozen projects that are literally changing the facts on the ground in transportation, showing that the technologies to achieve net-zero in transportation already exist. The Ray has experienced phenomenal growth since its first project in 2015, the installation of a solar-powered electric vehicle (EV) charging station at the Georgia Department of Transportation rest area at the Georgia-Alabama state line.

Regional Strategy 
Led by the new Director of Regional Programs, Beverly West, The Ray has organized its partner agencies across the nation by four contiguous geographies to create a regional approach to service delivery, as opposed to centralizing all service delivery out of one office. The regional approach will be performed in collaboration with The Ray’s new GIS Manager, Jessie Hong-Dwyer, Ph.D., and the GIS team. Geographic Information Systems (GIS) play a crucial role in this regional work, by utilizing The Ray’s partnership with Esri and their powerful tools, the GIS team can identify, propose, and provide informed recommendations for suitable clean energy and connectivity projects within transportation infrastructure’s right-of-ways that effectively align with The Ray’s net-zero objectives.

“This team of teams strategy will allow The Ray to leverage our partnerships and the know-how that we have cultivated over the last decade to deliver technology solutions to transportation agencies across the country in an efficient and effective way,” said Beverly West, Director of Regional Programs.

Four Regional Managers will report to the Director of Regional Programs. The Regional Managers will be responsible for delivering services to transportation agency partners in the following regions:

Northeast / Mid-Atlantic: Maine, Pennsylvania, New Hampshire, Massachusetts, Maryland

Southeast: Georgia, South Carolina, Florida, North Carolina, Alabama, Louisiana

Midwest: Texas, Oklahoma, Ohio, Indiana, Minnesota, Michigan, Wisconsin

West: Montana, Colorado, Utah, Oregon, Washington, Arizona, California

About the Director of Regional Programs 
Beverly West is the Director of Regional Programs at The Ray. Prior to joining the team, she enjoyed a 23 year career with the Texas Department of Transportation (TxDOT). Most recently she served TxDOT as Section Director in the Strategic Planning Division with oversight of multiple programs including: Emerging Technologies Initiatives, Business Intelligence & Performance Management, Enterprise Policy Governance, Business Continuity of Operations, and Internal Risk Management and Prevention. Her teams created, led or facilitated enterprise initiatives such as the Connected & Autonomous Vehicle Task Force (CAV), Urban Air Advisory Committee (UAM), National Electric Vehicle Infrastructure (NEVI) plan, TxDOT’s Strategic Plan and COOP plans.

About the Western Regional Manager 
David Peters serves as the Western Regional Manager for The Ray. Prior to joining The Ray, he worked in various roles as the American Association for State Highway and Transportation Officials (AASHTO). Most recently he served as the Associate Program Manager for Resilience and Sustainability as a member of the Policy & Government Relations team. Before his time with AASHTO, David was a member of the Energy, Infrastructure, and Environment Division at 
the National Governors Association (NGA), working closely with Governors’ staff on energy and infrastructure policy.

About the GIS Manager 
Jessie Hong-Dwyer, Ph.D. serves as the GIS Manager for The Ray. Before joining the team, she was a professor of geography, teaching introduction to advanced-level GIS courses and conducting numerous GIS research projects for more than ten years at the University of West Georgia. She has collaborated with the Georgia Department of Education, Cobb County School District, and the National Geographic Society as a GIS professional. Jessie is a published author of 35+ scientific articles and a presenter of 25+ papers at regional, national, and international professional conferences. She holds a Ph.D. in geography from the University of Colorado Boulder, an M.S. in geography from San Diego State University, and a B.S. in geography from Ohio State University.

About The Ray 
The Ray is a 501(c)(3) nonprofit charity and net-zero highway testbed, located on 18 miles of Interstate 85 between Lagrange, Georgia and the Georgia-Alabama state line. This stretch of interstate is named in memory of Ray C. Anderson (1934-2011), a Georgia native recognized as a leader in green business when he challenged his company, Interface, Inc., to pursue a zero environmental footprint. Our mission is to reimagine how we connect our communities, our lives and the world in a way that is safer, more responsive to the climate, more regenerative to the environment, and more capable of creating economic opportunity through innovative ideas and technologies that will transform transportation infrastructure. The Ray Highway is paving the way for a zero carbon, zero waste, zero deaths highway system that will build a safer and more prosperous future for us all. Learn more at www.TheRay.org.

MEDIA CONTACT 
Sarah Grizzle, Director of Communications, The Ray 
310.699.2054 | sgrizzle@theray.org | @TheRayHighway

Originally published on Illumina News Center

Each person’s genetic code harbors millions of variants that differ from one individual to the next, and account for differences in health and disease risk. The more human genomes are sequenced, the more data researchers have to compare and predict which variants are most likely to cause disease. Despite the collective efforts of scientists and clinicians worldwide, the function of the vast majority of these variants remains unknown.

And genetic risk prediction has suffered from an ethnicity bias. Seventy-eight percent of the data in the Genome-Wide Association Study Catalog comes from people of European ancestry; when primarily European genomic data is used to train polygenic risk scores, it results in uneven performance when applied to other ethnic groups.

Sequencing a greater diversity of people is part of the solution, but even that can only tell us so much. “The main issue is that humans are pretty bottlenecked,” explains Kyle Farh, vice president of Artificial Intelligence at Illumina. “Even though there are 8 billion of us, our genetic diversity still looks like the original population of 10,000 common ancestors we’re all descended from. There just isn’t enough information to glean from the human species. It became clear several years ago that, to really understand the human genome, the data contained in human genome sequencing was not enough.”

Homo sapien DNA records the evolutionary history of a few hundred thousand years. But to avoid bias and learn even more about ourselves, scientists are broadening the search by tens of millions of years to study our more distant family, the primates.

DNA as living history

Evolution is the world’s longest-running experiment. Generation by generation, nature has been testing genes through random mutation—variants that harm an animal’s fitness are quickly removed from the gene pool, and ones that are neutral or beneficial survive to be passed on. “The results of these experiments are documented in every species’ genome,” Farh says. “They’re right there. It’s a living document.”

The taxonomic order “Primates” comprises over 500 species, encompassing apes, monkeys, prosimians like lemurs and loris—and us. We’re all descended from the same ancestors, and despite our wildly varied forms, living primates share more than 90% of our DNA with one another. Mutations that occur in chimpanzees or bonobos also occur in humans, and work from Illumina scientists shows that if a variant is tolerated by natural selection in another primate, it’s 99% likely not to cause disease in us. This isn’t true for more distantly related mammals—a variation that’s harmless in mice or dogs, for instance, may be pathogenic in gorillas or humans.

For the millions of years that primate species have been evolving in parallel, mutations that cause disease have been eliminated by natural selection. So by sequencing modern primates, we can improve our knowledge of which variants don’t cause disease.

Scientists at Illumina, in collaboration with those from 24 countries, just published the results of a vast study of primate genomes in four papers in the journal Science. The study sequenced over 800 individuals from 233 species of nonhuman primates, representing all 16 families and over 86% of living genera. But the sequencing was just the first step: Once they had all this data, they needed a way to interpret it. So they developed PrimateAI-3D.

An algorithm trained by evolution

The large language model ChatGPT has garnered much attention for its ability to generate humanlike responses to any prompt. Its artificial intelligence is trained on a massive data set of existing writing, so it can accurately predict the next sentences that would sound most natural based on the conversation up to that point.

PrimateAI-3D is an algorithm built on deep-learning language architectures analogous to those used in ChatGPT, but designed to model genomic rather than linguistic sequences. By presenting it with variants that are ruled out for disease in our macaque and orangutan cousins, its developers have effectively leveraged natural selection to train its parameters. The neural network learns where benign variants are represented in a gene and, by process of elimination, which regions are likely to cause disease if mutated. In this way, it learned how to accurately predict pathogenic variants in humans better than any human could.

The study published in Science compared PrimateAI-3D against 15 other machine-learning methods on four patient cohorts—one for neurodevelopmental disorders, one for autism spectrum disorders, one for congenital heart disease, and the UK Biobank. The first three cohorts are some of the largest studies to date that sequenced both an affected child as well as their unaffected parents; by contrast, the half a million genomes in the UK Biobank are mostly from healthy members of the general population. The study also evaluated the algorithm in the National Institutes of Health’s ClinVar database and other datasets.

Across six different clinical benchmarks, PrimateAI-3D outperformed all other existing methods by a wide margin. These findings will help researchers prioritize a small handful of variants that are most likely to affect a person’s health.

Furthermore, PrimateAI-3D demonstrated impressive improvements in predicting people at increased risk for common diseases in the UK Biobank cohort, especially across non-European ethnic groups. “What we find is that 97% of otherwise healthy people in the general population carried highly actionable variants for clinically relevant conditions,” says Farh, one of the study’s principal authors. “Up to now we’ve learned that you need genome sequencing if you have a rare disease or cancer—but actually it looks like every healthy person in the population has highly impactful variants in our genomes that are clinically relevant and are important to be informed about.”

Giving back to the gibbon and baboon

On top of the benefit to human health, these efforts could also be instrumental for primate conservation. “We’re in a hurry to collect this data because the majority of these species are on a fast track to extinction,” Farh says. The genetic diversity recorded in an animal’s DNA tells us not only how many individuals remain in that species’ population, it also tells the story of that population’s size over time, back through the generations. “That tells us how quickly the species is declining, and how much time they have left. That’s in their genomes.”

PrimateAI-3D’s developers found that its performance scales directly with the size of the dataset used to train it, so the more primate species they can sequence, the better the tool can become. The monkeys and apes can help us, and we can help them. “I think we’re only at the beginning,” Farh says. “There’s a tremendous amount that can be learned here. And the idea that you can learn more about our own species from other species is, I think, deeply romantic.”

PrimateAI-3D will be made broadly available to the genomics community in an upcoming release of Illumina Connected Software products.

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