FORESEE PHARMACEUTICALS PRESENTED POSTER ON MMP-12 INHBITOR, FP-020, IN GENETIC MODEL OF SARCOIDOSIS AT THE WASOG 2023 INTERNATIONAL CONFERENCE ON SARCOIDOSIS AND INTERSTITIAL LUNG DISEASES (ILDs)

Mice with a conditional deletion of the Tsc2 gene in CD11c+ cells leading to chronic activation of mTORC1 signaling in myeloid cells, caused spontaneous cardiac sarcoid-like granulomas. Inhibiting MMP-12 with FP-020 attenuated macrophage infiltration, macrophage clustering, decreased…